The short film Alma & Esperanza , directed by Itandehui Jansen, a PhD candidate (directing supervisor Professor Dr. Kitty Zijlmans) of the Leiden University Academy for Creative and Performing Arts, has been selected to the Short Film Corner of this year’s edition of the Cannes International Film Fe…

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Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

To strenghten ties with the public, press, other academics and wider society, LION employs an outreach officer.

Natural product inspired antibiotics to address resistance

Tools and Data of the department of Environmental Biology

Special Issue in: Visual Anthropology, Volume 29, Issue 3, 2016

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

The Buzz is equipped with the latest technology in the world of fitness: eGym. Combined with our functional- and cardio training equipment, free weights and group classes, we offer a complete fitness concept.

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Neurobiological, cognitive and behavioural measurements of normal and abnormal child development.

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

Supervisor: Gerard van Westen

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

The division of Drug Discovery and Safety combines the former divisions Toxicology and Medicinal Chemistry.

Generally the data from remote sensing surveys - the scanning of the earth by satellite or aircraft in order to obtain information about it - is screened manually in archaeology. However, constant monitoring of the earth's surface causes a huge influx of data of high complexity and high quality. To…

Heart failure is a major health care problem with high mortality.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel, and zinc based on biotic ligand models (BLMs).

Research projects

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: Prof.dr. M.K. Richardson

How can prospective LCA be streamlined in a way that its practical application in research and technology development increases?

Currently, Navigation Lab Leiden works on three main themes: navigation ability, spatial abilities, novel techniques in neuropsychology.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

The Cinematic Santri explores the rise and course over the last ten years of cinematic practices among a younger generation of NU associates (Nahdlatul Ulama), the largest traditionalist Muslim group in Indonesia and elsewhere.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Kunst en vrije tijd, Kunst en vrije tijd

Make sure you have a suitable place to work or study at home

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

A novel in vivo model system for studies on glucocorticoid resistance

In support of the research and education, the Leiden Institute of Advanced Computer Science (LIACS) has a Research and Education laboratory at its disposal. Within this environment, we can offer machines that go beyond normal office automisation and production.

Our response to stress is regulated by the ‘bliss molecule’ anandamide but how exactly remained unknown. Until recently, that is. Elliot Mock has now succeeded in developing a new substance that reduces anandamide, called LEI-401. This has made it easier to conduct research into the role of anandamide…

Research facilities within reach of LIBC members:

Lezing

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

How can zebrafish research help understanding human diseases?