Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?

Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols aims to be useful as an up-to-date reference work for scholars in the bacterial chromatin field, those entering the field from adjacent research fields, and scientists in the eukaryotic chromatin field.

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

John van Noort

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Subproject of

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

How did people in the latter part of the Late Bronze Age organize themselves in order to be able to erect massive structures such as tholos tombs, citadels and how did they interact with these materials and circumstances while constructing? What impact did such a changing landscape have on their day-to-day…

Archaic and Classical architectural terracottas constituted an integral part of the architecture of monumental buildings at Akragas. These objects therefore provide unique insights into the built environment of sanctuaries at this important Greek colony in Sicily. This research's multi-disciplinary…

Subproject of

The hypothesis of this research is that the municipality used the impressive the Town Hall to enforce its rule and represent its political ideas and make use of sources such as biographies, poems, pamphlets, sermons and governmental documents.

This programme aims to identify the intellectual contexts that were of importance for the architectural theory of the period, and especially to clarify the relation of architectural theory to primitivism.

The civilizations of ancient China and Mesoamerica, although not historically related and obviously different in many specific aspects (such as language and writing), show many interesting commonalities and similar tendencies in their cultural manifestations.

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle and Lars Jeuken.

Promotie

Why is there no Northeast Asian security architecture? Assessing the strategic impediments to a stable East Asia. In this article, published in 'The Pacific Review', the authors Wang (Peking University) en Stevens (Leiden University) discuss the reasons why.

In what ways and to what ends did Parisian buildings overwhelm the early modern public? This study is concerned with the experience of the sublime in architecture in seventeenth-century Paris.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

This work represents the final results of several years of research within the Maya region. It deals with the relations between architecture and urbanism with landscape and astronomy.

The goal of this book is to place architectural studies, in which people’s interactions with each other and material resources are key, at the crossing of both landscape studies and material culture studies, where it belongs.

This beautifully illustrated volume investigates the social life of objects moving between the Middle East and the West, revealing the range of agencies and subjectivities involved in their trade and reuse.

Knowledge and culture subproject 3:

Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.

What are the precise identities, possibilities and current practice examples of the various time frames in music and what bearings do they have individually and in combinations on the speed of the music?

A full overview of MacBio PhD Theses.

Promotores: H. Schiessel, G.T. Barkema

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Key research articles and book chapters of the Chromatin group.

Studio Leon Thier Architectuur/Interieur is the architectural firm behind the interior design of Wijnhaven, and with this project they have been nominated for the architectural award the ‘New Berlage flag’. The award has been introduced by the Hague Architecture Café (HaAC) and the BNA. The award goes…

The 18th-century rediscovery of the three archaic Greek-Doric temples in Paestum in southern Italy turned existing ideas on classical architecture upside down...

Leiden physicist Maarten Kruithof has discovered how our DNA is infallibly able to fold itself and to unfold again. In his dissertation he demonstrates how DNA is folded in a single long, very flexible spiral.

The Berlagevlag goes to the Wijnhaven District, a design by Geurst & Schulze architects, with its Leiden University interior designed by Studio Leon Thier architecture with the assistance of StudioLEFT. The Hague Architecture Café (HaAC) and the BNA in The Hague want to use the award to promote the…

Exposition illustrious works by Piranesi now on view in Digital Special Collections.

An international partnership of brain researchers from 35 research centres - from the US to China - including the Leiden Institute for Brain and Cognition (LIBC), has collected resting-state functional MRI data from more than 1400 healthy volunteers and put the information online so that it is available…