Dementia is a progressive disease, diagnosed at a relatively late stage when intervention may not be effective. Aim of the research is to study scans of brain networks to help discover the early network changes related to dementia. Early diagnosis may benefit effectiveness of future treatment.

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

How is structural and functional brain development related to behavioral change in cognitive-control, impulse regulation, and socio-emotional functioning?

Nowadays children grow up with social media. This may influence the development of brain regions involved in social interaction. In their review article in Nature Communications, Crone and Konijn illustrate how neuroscience can contribute to a better understanding of how media and peers influence adolescents'…

What is the relation between brain development and social and cognitive development across childhood, adolescence and adulthood?

An Integrative Approach to the Hominin Record

Researchers have been working for centuries in mapping the human brain. But in the year 2017 some brain structures remain still not well mapped, especially those located at the brainstem. In this paper, we quantified the test–retest reliability of imaging the brainstem nucleus locus coeruleus in vivo…

Our goal is to develop usable, practical and meaningful Brain-Computer Interfaces to diagnose, restore, repair and enhance functions of the impaired brain.

In the Brain and Education Lab we study the development of complex cognitive processes involved in skills such as learning, reading and math.

Fundamental insights into the working of the adolescent brain help lecturers and parents to teach adolescents to function better. Professor Eveline Crone studies executive functions – such as planning and behaviour – in the adolescent brain.

Are disturbances to the brain, such as Alzheimer's or autism, linked to specific defects in the underlying communication networks in the brain? If this is the case, subtle changes in the networks can act as a marker for brain disturbances. Neuroscientist Serge Rombouts will be investigating this, together…

What is the relation between brain development and social and cognitive development across childhood, adolescence and adulthood?

The more opportunities a child has to learn and develop, the stronger his or her future position in society. Leiden University investigates how the brain picks up information, and how learning processes can be influenced positively.

The Leiden Institute for Brain and Cognition (LIBC) is a network focusing on science valorisation and outreach, stimulating interdisciplinary exchange of knowledge and expertise on topics related to brain and cognition.

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The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

This study is the first to directly relate brain development to sex differences and school performance. The results debunk the myth that brain development is slower in boys.

What is the neural basis of social decision-making across childhood, adolescence and adulthood and what are the developmental patterns in terms of behavior and brain activation?

This project looks at how the native language influences processing mechanisms of non-native language(s) as well has how it influences brain structure and functional connectivity.

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

Cognitive processes of learning with a focus on reading comprehension and the development of mathematical skills.

Promotie

A neurobiological perspective on individual differences in social competence

Can playing certain games decrease cognitive decline or even enhance cognitive performance in the aging population?

The recent terrorist attacks in Europe are presumably not just acts committed by individuals, but acts facilitated by larger jihadist networks. But how do such networks operate? Understanding their modus operandi can be useful knowledge to counter terrorist threats.

Promotie

This dissertation studies how domestic regulatory agencies and the officials representing them are influenced by and deal with the increasingly complex transnational environments in which they have come to operate. Based on (social) network analysis it demonstrates how decisions of domestic agencies…

How do we address the pressing challenges posed by large-scale networks?

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

The Leiden Complex Networks Network (LCN2) aims at bringing together scientists from different disciplines, based on a common interest in both theoretical models and empirical analyses of networks and graphs.

The LLC is a network organisation with various national and international partners in academia and public, private and social organisations.

This interdisciplinary community aims to facilitate tight collaboration between all faculties of Leiden University on the subject of Artificial Intelligence. The Future of AI is Bright!

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

Modelling supra-regional communities in the early 3rd Millennium BC

How can citizen science be used to communicate and provide data for social network analysis?

Below you can find lists of Leiden-based and international organizations working on Central Asia, and an overview of useful resources on Central Asia.

The ‘Food citizens?’ project is assisted by an advisory board, consisting of academics and stakeholders.

What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?

LeiCenSAA is dedicated to the study of Ancient Arabia and the sharing of knowledge and expertise on this topic. Thefore it aims to collaborate closely with other research in the field.

The Leiden University Sustainability Network is the platform for Leiden University staff to combine their efforts and support each other in making our university more sustainable.

The LGBT+ Network offers a platform for all lesbian, gay, bisexual, transgender and queer staff and students at Leiden University.

This dissertation consists of two parts, with the common theme

Both within Leiden University and in the external partner universities PhD-research is conducted which is directly or indirectly related to regional integration.

The focus of this programme is the inter-community social relationships and transformations of island networks in the Lesser Antilles across the historical divide.