This volume explores the nature of ellipsis, the core phenomenon that results in various types of omission in sentences.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Scientific integrity is an important element in the PhD trajectory, and is addressed in several different settings.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Kohei Suzuki is Assistant Professor at Institute of Public Administration. This study carries several important implications for understanding the policy impacts of a graying population and for studies of the welfare state, in general.

Promotor: G.P. van Wezel

The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

Electrocatalysis will play an increasingly important role in future in the transition to more sustainable energy. Thanks to chemist Isis Ledezma Yanez, we now know more about the hydrogen evolution process. PhD defence on the 9th of June.

Detecting molecules with temperature instead of chemical reactions: that’s what scientists from the Leiden Institute of Physics want to do. They are developing a sensor that utilizes special nanoparticles to keep track of certain molecules. In this way, they can for example see how well new drugs do…

Leiden chemists Marc Koper and Ian McCrum have discovered that the degree to which a metal binds to the oxygen atom of water is decisive for how well the chemical conversion of water to molecular hydrogen takes place. This insight helps to develop better catalysts for the production of sustainable hydrogen,…

On Friday October 25th the fourth annual Jan Reedijk Symposium will be held. The main lectures of the day will be

Do you want to make contact with talented young people at an early stage of their career? Career Services can help you can get in touch with students and young alumni of Leiden University.

The curriculum of this bachelor’s programme gives you an understanding of artificial intelligence and data science with a solid basis in computer science. Both artificial intelligence and data science are broad disciplines that require essential and foundational underpinnings.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Subproject of

FitDis! is designed to ease the determination of binding energy and oligomeric state of coiled coil peptides. It allows direct fitting of concentration dependent thermal peptide unfolding curves measured for instance by CD–spectroscopy.

Double Bind. Public service professionals coping with contrasting demands. How do public service professionals align their PSM with contrasting demands set by the organizational and social contexts in which they work?

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Source: Mediators Inflamm (2014)

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On 23 juni 2019, Zygimantas Juska defended his thesis 'The Role of Collective Redress Actions to Achieve Full Compensation for Violations of European Union Competition Law'. The doctoral research was supervised by Prof. dr. T.R Ottervanger.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

On 11 February 2020, Clara van Dam defended her thesis 'Guidance documents of the European Commission in the Dutch legal order'. The doctoral research was supervised by Prof. W. den Ouden and Prof. J.E. van den Brink (UvA).

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

This collection brings into conversation several kinds of scholarship on medieval authorship which have tended to remain separate over the last two to three decades, a period of steadily increasing scholarly interest in this topic.

Leiden University has made history with its many scientific discoveries; a history that is also illustrated in a variety of books and films.

In this article, Gerrit Dijkstra and Jos Raadschelders from the Institute of Public Administration, argue that Bosnia-Herzegovina survives so far on the basis of negative legitimacy.

Congres/symposium

Koper

At Leiden Observatory, researchers investigate the origin of stars and their planetary systems. They detect and characterize planets around other stars (exoplanets). They study how stars and planets form. And they follow molecules from interstellar clouds to nascent planet systems. This way they address…

Indira Nederpelt presented her work at the FIGON Dutch Medicines Days held on October 6 2014 in Ede and provided a kinetic perspective on the characterization of clinically used GnRH peptide agonists.

Maris Vilums was elected as the winner of the annual PhD Competition at the LACDR Spring Symposium, May 23rd 2013, with his oral presentation:

Rather than one key and one strong lock, biology often uses tens or hundreds of weaker links to bind parts together, such as cells membranes. This allows for selectivity and also reversibility: the binding can also be undone. Researchers first caught this phenomenon using spheres or colloids, and published…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

The Faculty of Medicine

Despite an increased EU role in the preparedness, monitoring and coordination of health emergencies over the past two decades, Member States’ responses to the first wave of COVID-19 were surprisingly uncoordinated. In light of calls to improve cooperation regarding future health emergencies, this article…

How did dynastic organization – that it, the employment of non-ruling family members and the development of dynastic traditions and concepts – influence state formation in both Catholic Europe and Muslim West-Asia?

Following its foundation in 1575, Leiden University was quick to incorporate Roman goddess Minerva in its coat of arms. This explains why Rembrandt’s Minerva from 1635 can be seen on the façade of the Academy Building, which has been in use by the University since 1581. This is where, in the Senate…

LUCAS members are experts in the fields of literary history and theory, film and media studies, and art, architectural, and book history.

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.