Leiden chemists have proposed a new model for enzymatic reactions, in which the flexibility of the substrate is much more important than previously thought. Their results are paradigm-shifting and could have major implications for drug research and enzyme engineering. Publication in Angewandte Chemi…

Why obey the state? Dorota Mokrosińska presents a fresh analysis of the most influential theories of political obligation and develops a novel approach to this foundational problem of political philosophy, an intriguing combination of the elements of natural duty and associative theories.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

This book is an examination of why and how the elective principle, already established in Transylvanian and Polish political culture in the late medieval period, was transformed in the early elections of the 1570s.

Can cyclic peptides provide a new generation of antibiotics?

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

What are the essential determinants of (dis)trust? And, what are the effects of being (dis)trusted?

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Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

The research program of the QO group has three leading themes: Optical Physics, Quantum Optics, and Photon-Matter Interactions. We work mostly at the boundaries between these themes with entanglement as a bridging and binding agent.

The Sport Data Center (SDC) consists of the data science disciplines of Leiden University and Technical University Delft, combined with the sport science branches of the Amsterdam Institute for Sport Science and the Sport Engineering Institute of the Technical University of Delft.

Promotor: Prof.dr. M. Ubbink

Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.

Lezing

Juurlink

Considering the absence of the human performer within a performance installation, the research centres around what is left of the human through traces such as sound or recorded voices, images, videos or movement and gestures. What do we perceive as ‚present‘, once the human is removed from the centre…

In the Catalysis and Surface Chemistry group, we investigate how catalysis works on the molecular level. The group is divided in six subgroups, focusing on different aspects of heterogeneous catalysis, homogeneous catalysis and electrocatalysis.

The starting point of Hermans' research is how both children's physical play and dance improvisation by professionals can be considered somatic practices where sense-making manifests itself in and between bodies, and through movement.

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

The "Van Marum Colloquia" are a collaborative lecture series between the LION and LIC institutes, focusing on fundamental and applied surface science.

Promotie

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

As part of your application procedure for the bachelor’s programme English Language and Culture, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also…

As part of your application procedure for the bachelor’s programme Philosophy: Global and Comparative Perspectives, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations.…

As part of your application procedure for the bachelor’s programme Linguistics, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer a number…

As part of your application procedure for the bachelor’s programme Arts, Media and Society, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer…

Relevant publications of the CIGR participants.

Promotie

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

Natural product inspired antibiotics to address resistance

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

On 11 November 2021, Evelien Campfens defended the thesis 'Cross-border Claims to Cultural Objects'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. W.J. Veraart (VU Amsterdam).

Promotor: Prof.dr. M. Ubbink

Supervisor: Gerard van Westen

This volume explores the nature of ellipsis, the core phenomenon that results in various types of omission in sentences.