Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Two PhD defences on 9 June by behavioural biologist Errol Neo and underwater acousticianan Özkan Sertlek relate to measuring noise in the North Sea and the harm this noise can do to aquatic animals and their surroundings. Little is known about how harmful human noise can be to aquatic animals.

A multiple isotope approach to human-animal dynamics in the Lesser Antilles across the historical divide

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

This project is a collaboration between Sanquin, LUMC and LIACS. It focuses on the development of meta-modelling methods and tools for the exchange, analysis, and publication of anonymised patient data. Measures are being constructed to evaluate both the level of privacy and the extent to which an anonymized…

Promotor: C.J. ten Cate

Children’s clothes are full of cute, fun and cool animals. Researcher Michiel Hooykaas investigated which animals were most prevalent, to see how cultural product can influence the knowledge of biodiversity.

Promotor: J. A. Bouwstra

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

Dutch children’s picture books are full of animals, but mainly mammals are portrayed. Especially pets and exotic animals are popular. A large part of the Dutch fauna is less visible, but biologist Michiel Hooykaas of Leiden University sees plenty of opportunities for a more biodiverse book world.

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Many dangerous diseases such as COVID-19, Ebola and Q fever have jumped from animals to humans. But it is not only because of these diseases that we should include animals in our health policy, but also because of their right to health, writes PhD candidate Joachim Nieuwland. PhD defence on 13 May.

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

Face masks and gloves designed to protect us are, in fact, dangerous for the animals around us. Scientists from Leiden warn that throughout the world, on land and in the water, animals are ingesting corona waste, or getting entangled in it. The two biologists are asking for everybody’s help to better…

From 16 to 19 September 2021 a hybrid conference will take place on animation in the Middle Ages. This conference is a cooperation between the University of Bergen (Norway) and the A. Zelwerowicz National Academy of Dramatic Art in Warsaw, Branch Campus in Bialystok (Poland).

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

Heart failure is a major health care problem with high mortality.

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463

How can species literacy in the Netherlands be explained and improved?

If you'll soon be getting a COVID-19 vaccine, you might just get the Johnson & Johnson (Janssen) one. This vaccine was developed for the most part in Leiden – and this is no coincidence. Watch the animation below about the development of one of the vaccines in the fight against COVID-19.

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…

Tapping to a rhythm, recognizing sound patterns and enjoying music: For people, it is common sense. But is this also the case for animals? It is the research topic of Michelle Spierings, a researcher at the Institute of Biology Leiden, and it is nominated for the Klokhuis Wetenschapsprijs.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

A Dutch-language video shows children their new life during the corona crisis and gives them some guidelines to help them feel less worried. The short animated video was made by two German researchers with whom child psychologists Anke Klein and Annelieke Hagen are working. ‘With our translation, this…

Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem Schouten-Straatman changed this by improving the existing models. ‘I hope that one day we will…

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

When professor Frank Israel graduated at Leiden Observatory some forty years ago, little did he know that one of his theories would be making headlines in 2018 - in the form of a 3D animation on the Internet, no less.

Source: Eur J Med Chem (2015)

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

Source: Mediators Inflamm (2014)