Promotor: Prof.dr. E. Deprettere

The Animated Image addresses the entire range of contexts in which images were described by Roman authors as being animated, as well as the accounts that Roman writers produced to explain the animation of inanimate matter.

Kunst en vrije tijd, Kunst en vrije tijd

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

... which build on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

Leiden University investigates biodiversity not only in the Netherlands, but also abroad, with the goal of improving global nature conservation. We do so in collaboration with local universities. Education is also high on our agenda.

We are developing the conceptual framework, which is new to this taxonomic group, and evaluate the current state of the art with respect to all critical parameters and transfer functions for a fully developed Population Consequences of Acoustic Disturbance (PCAD) model.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Kunst en vrije tijd, Kunst en vrije tijd

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Peter Grunwald

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Can birds - like people- ‘see’ voices and learn how to sing by listening and watching?

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

ASLU 14

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

A research agenda

In this research project child language phonology is studied from the perspective of a psycholinguistic speech-production model and this model is in turn studied from the perspective of developmental phonology.

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Hekmat Dirbas defended his thesis on 14 February 2017

The Agent Based Modelling for Archaeologists (ABMA) project is dedicated to developing Open Educational Resources (OERs) and accompanying materials for agent-based modelling (ABM) in Archaeology.

Are predictive archaeological maps a reliable tool to play an important role in the spatial planning? One of the goals of this project was to develop best practices for the production and application of the models.

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Speakers from all over the world offered their interesting views on the relationship between humans and animals during the LUCAS Graduate Conference, based around the central theme ‘Animals: Theory, Practice, and Representation’.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotie

The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.

We should assume that animals can have feelings too. From an ethical point of view this should inform our dealings with animals, researchers from Leiden University and Utrecht University argue in an opinion article that was published in the scientific journal Affective Science on Thursday 10 March.

Promotor: Prof.dr. J.N. Kok

This project contemplates an ethics of difference and singularity that can effectuate a displacement of anthropocentrism and radical transformation in the way we understand and approach relationality across species borders. PhD defence on 16 December 2019.

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…