Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Below you can find an answer to the most frequently asked questions about our programme. Is your question not in this FAQ? Please contact us for a personalised answer via: masterva@lumc.nl.

The Mid Upper Palaeolithic of Eurasia 30,000 - 20,000 BP

Promotor: Prof.dr. J. Kuiper

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

How are the epidermal lipid pathways involved in health and disease.

This Research project is funded by the 7th European Community Framework Programme, with additional funds from NWO Aspasia grant, and in collaboration with University of California, Berkeley.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Edited by Dr. S. Arnoldussen and Prof. dr. H. Fokkens

On 27 June 2019, Barry Bussey defended his thesis 'The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age'. The doctoral research was supervised by Prof. dr. P.B. Cliteur.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Leiden University archaeologists are reconstructing houses from the Stone Age, using only resources available during that period. This method offers surprising insights into the ingenuity of our distant ancestors, and challenges existing archaeological views.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

Memory loss and confusion are signs of Alzheimer’s disease. Physicists Serge Rombouts and Martina Huber have developed new methods to help medical science get to the bottom of this insidious disease.

We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

ASLU 7 - A.E. de Hingh

Amerindian settlement patterns and early colonial cartography in Northern Hispaniola

The handbook is a wide-ranging survey of a crucial period in prehistory during which many social, economic, and technological changes took place. Written by specialists in the field, the book provides coverage both of the themes that characterise the period, and of the specific developments that took…

On 9 May 2018, Roy van Keulen defended his doctoral thesis 'Digital Force: Life, Liberty & Livelihood in the Information Age'. The doctoral research was supervised by Prof. dr. A. Ellian.

Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

Postdoc Lucia Bossoni has received an NWO Veni grant to research brain diseases for the next three years. She will work in labs at both the LUMC and the Leiden physics institute.

Also including: Wateringen 4 & Acquiring a taste.

The conquest by Rome brought profound changes to large parts of Europe. Unprecedented infrastructural works were created, towns sprang up, a ribbon of fortresses was laid out along the frontiers.

How did Anglo-Saxons reflect on the experience of growing old? Was it really a golden age for the elderly, as has been suggested?

To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.

The Case of the Painted Plaster

It recently emerged that a Swiss firm secretly owned by the CIA and the West German intelligence service BND had been selling manipulated coding equipment to numerous governments, including allies, to spy on them through a Swiss cover firm for years.

The present volume focuses on the political perceptions of the Hajj, its global religious appeal to Muslims, and the European struggle for influence and supremacy in the Muslim world in the age of pre-colonial and colonial empires.

From as early as classical antiquity there has been an interplay between literature and medicine.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.

Legibility in the Age of Signs and Machines offers a compelling reflection on what the notion of legibility entails in a machinic world in which any form of cultural expression – from literary texts, films, artworks and museum exhibits to archives, laws, computer programs and algorithms – necessarily…

The abundance of images in our everyday lives-and the speed at which they are consumed-seems to have left us unable to critique them. To rectify this situation, artists such as Daniel Richter, Jaune Quick-to-See Smith, and Artur Zmijewski have demonstrated that painting is brilliantly equipped to produce…

Source: Mol Psychiatry (2015)

The ability to create objects and structures with our hands has been essential to human development. This ability is something modern society is at risk of losing. Leiden archaeologists gather knowledge about ancient processes of ‘making and creating’ over the centuries, knowledge that helps our current…

Introduction

Alzheimer’s disease and cancer are two examples of diseases that are related to malfunctioning cellular patterns. The examination of cell tissue, however, takes a lot of time and generates a lot of data. To make the analysis of data easier, Antonios Somarakis of the Data Science Research Programme (DSRP)…

The brain is a complex organ, and researching medicine to treat brain disorders is equally if not more complex. Elizabeth (Liesbeth) de Lange, Professor of Predictive Pharmacology, calls for a structured approach. ‘In effect, it's like playing Mastermind.’ Inaugural lecture on 22 March.