We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: F.S. de Boer Co-promotor: P. T. de Gouw

This project aims to improve understanding of, and responses to, the phenomenon of lone actors through analysis of comprehensive data on cases from across Europe.

The term “Lone Actor” has been applied to a variety of violent individuals who are thought to act out of ideological motivations using terrorist tactics.

This article provides an in‐depth assessment of lone actor terrorists’ attack planning and preparation.

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

Promotor: Roeland M.H. Merks

This computational approach to the complexity of text comprehension is useful for describing the cognitive processes involved.

Existing work in probabilistic language modeling can be mostly divided into two categories:

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Promotor: Prof.dr. E. Deprettere

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Promotor: Prof.dr. B.R. Katzy, Co-promotor: R. Ortt

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Within the domain of health there can clearly be seen some new developments, for example e-healthcare solutions, which change the health landscape. However, in many African countries health care and public health are not sufficient enough.

... which build on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Identifying the gaps in the legal framework for EU activities in the maritime security domain, and specifically in the areas of combating piracy, human smuggling or trafficking and drug trafficking.

Kunst en vrije tijd, Kunst en vrije tijd

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

My research project aims to analyze reasons of the European Union’s (EU) inadequacy to develop a strong Common Security and Defense Policy (CSDP) with regard to the role of main EU member states, namely Germany and the United Kingdom (UK) and find the answer of how the EU overcome the CSDP question…

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Peter Grunwald

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

ASLU 14

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

A research agenda

In this research project child language phonology is studied from the perspective of a psycholinguistic speech-production model and this model is in turn studied from the perspective of developmental phonology.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Are predictive archaeological maps a reliable tool to play an important role in the spatial planning? One of the goals of this project was to develop best practices for the production and application of the models.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…