In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with the University of Havana.

Microscopic spheres that can self-propel through a liquid move faster over a hydrophobic surface than they do over a hydrophilic surface. ‘This was a surprise,’ says Stefania Ketzetzi, the researcher who discovered the effect. Understanding how these artificial spheres move is important for understanding…

Promotie

From a new generation of antibiotics and more-effective vaccines to a map of dark matter and new light on Hindu traditions. Four researchers from Leiden University have received a prestigious €2.5m ERC Advanced Grant to develop their research.

Marieke Liem, professor at ISGA, discusses how the number of drug-related murders has not decreased in the last years

Gold Matters: Sustainability Transformations in Artisanal and Small-scale Gold Mining: A Multi-Actor and Trans-Regional Perspective.This project explores whether a transformative approach towards sustainability can arise in Artisanal and Smallscale Gold Mining (ASGM).

On 14 April, the National Growth Fund awarded million euros in grants to two consortia in which Leiden's science faculty is involved. Pharma-NL will receive 80 million euros and Oncode-PACT 325 million euros. Pharma-NL wants to make medicines available to the patient faster and more sustainably. Oncode-PACT…

Thomas Hansen is our Leiden Institute of Chemistry's nominee for the C.J. Kok Jury Award 2020.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Rob van Wijk gave an interview on the role of zebrafish in drug discovery and development, published in FIGON’s journal Medicines as a preview of LACDR’s representation at the PhD competition during the Dutch Medicines Days (DMD). The entire interview can be read below.

Rosan Kuin started her PhD in July at the LACDR under supervision of prof. Gerard van Westen and Dr. Meindert Lamers. She completed a BSc. in Pharmaceutical Sciences at the VU University in Amsterdam in 2017. After that she started two master programs, Drug Discovery & Safety with a specialization in…

Our education programmes span the entire spectrum of Analytical BioSciences, Biopharmaceutics, Drug Delivery Technology, Medicinal Chemistry, Pharmacology and Toxicology.

The global outbreak of coronavirus and the government measures to slow its spread are having a huge impact on society. Our researchers reflect on this impact from the perspective of their own discipline – or are even working on solutions.

In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

The American president Trump is considering military intervention in Mexico to get rid of the drug cartels once and for all, but Mexico is not interested in other countries' interventions. According to Jelle van Buuren, Assistant Professor at the Institute of Security and Global Affairs, Trump's much…

This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Microneedles represent promising tools for delivery of drugs to the skin. However, before these microneedles can be used in clinical practice, it is essential to understand the process of skin penetration by these microneedles.

Lezing, Lunch Research Seminar

Development of Natural Resource for New Medicines

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

In prehistoric times there was a huge wave of migration, from the steppes in Russia and Ukraine to West Europe. The newcomers’ genes began to dominate. Archaeology research in Leiden into burial mounds in the Veluwe and Utrechtse Heuvelrug areas of the Netherlands yielded this spectacular conclusion.…

TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…

Archaeologist Bjørn Peare Barthold suspected farmers in a doctorless 19th century Dutch village may have been self-medicating to manage pain and disease. By examining the skeletons' dental calculus this hypothesis could be tested. Science Magazine interviewed him about this new technique.

Promotie

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Pim Schipper has won the third prize for his oral presentation during the tenth biennial meeting of the Globalization of Pharmaceutics Education Network (GPEN), which was held from 27 – 30 Aug 2014 at the University of Helsinki, Finland.

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Since the start of the Corona crisis, several COVID-19 related research and teaching projects were started at LACDR. The computational and teaching activities started right away, as well as a large-scale metabolomics screening program by Thomas Hankemeier’s group. Other experimental activities are still…

There are a number of vaccines that require animal testing in their production. Thomas Michiels developed a replacement lab test that allows manufacturers to achieve the same result, without involving animals. The next step is that the test has to be validated by pharmaceutical companies and has to…

Cursus

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Researchers Indu Khatri, Frank Staal and Jacques van Dongen from Leiden University Medical Center (LUMC) have published a perspective article in Frontiers in Immunology about coronavirus and its characteristic ‘spike protein.’ They predict which antibodies would provide the best protection against the…