960 zoekresultaten voor “yeast screening” in de Publieke website
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The Cinematic Santri : Youth Culture, Tradition and Technology in Muslim Indonesia
The Cinematic Santri explores the rise and course over the last ten years of cinematic practices among a younger generation of NU associates (Nahdlatul Ulama), the largest traditionalist Muslim group in Indonesia and elsewhere.
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Diagnosis and treatment of obese children with insulin resistance
Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst
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Materials Innovative Technologies Assessment (MIN-TEA)
How can prospective LCA be streamlined in a way that its practical application in research and technology development increases?
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Research
Currently, Navigation Lab Leiden works on three main themes: navigation ability, spatial abilities, novel techniques in neuropsychology.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Improvisations in phototrophy
Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.
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Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
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Outreach and Science Communication
To strenghten ties with the public, press, other academics and wider society, LION employs an outreach officer.
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NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
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Tools and Data
Tools and Data of the department of Environmental Biology
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Visual Revolutions in the Middle East
Special Issue in: Visual Anthropology, Volume 29, Issue 3, 2016
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Fitness
The Buzz is equipped with the latest technology in the world of fitness: eGym. Combined with our functional- and cardio training equipment, free weights and group classes, we offer a complete fitness concept.
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Endocannabinoids in health and stress
How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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Strategy
The division of Drug Discovery and Safety combines the former divisions Toxicology and Medicinal Chemistry.
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Projects
Research projects
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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The use of Deep Learning in the automated detection of archaeological objects in remotely sensed data
Generally the data from remote sensing surveys - the scanning of the earth by satellite or aircraft in order to obtain information about it - is screened manually in archaeology. However, constant monitoring of the earth's surface causes a huge influx of data of high complexity and high quality. To…
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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PNEC-pro
PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel, and zinc based on biotic ligand models (BLMs).
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Chemical Similarity: Structuring Risk and Hazard Assessment
At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.
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Lab facilities Clinical Neurodevelopmental Studies
Neurobiological, cognitive and behavioural measurements of normal and abnormal child development.
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Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice, Nat. Chem. Biol. 2020
N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.
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In silico characterization of a GPCR focused library
Supervisor: Gerard van Westen
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The importance of friendships in reducing brain responses to stress in adolescents exposed to childhood adversity: a pre-registered systematic
Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.
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Cancelled: International Women’s Day 2020: Film Screening & Discussion with Oxfam Novib
Lezing
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Elliot Mock
Our response to stress is regulated by the ‘bliss molecule’ anandamide but how exactly remained unknown. Until recently, that is. Elliot Mock has now succeeded in developing a new substance that reduces anandamide, called LEI-401. This has made it easier to conduct research into the role of anandamide…
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LIBC Research Facilities
Research facilities within reach of LIBC members:
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Study and working conditions
Make sure you have a suitable place to work or study at home
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
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Our facilities
In support of the research and education, the Leiden Institute of Advanced Computer Science (LIACS) has a Research and Education laboratory at its disposal. Within this environment, we can offer machines that go beyond normal office automisation and production.
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Vision and Imaging
On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…
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Division of Drug Discovery & Safety
We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.
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ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
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New antibiotics
Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.
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PhD position to study regulation and transport of a novel anti-diabetic plant derived metabolite
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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NWO Projectruimte Grant for DNA Flexibility Research
Theoretical physicist Helmut Schiessel receives an NWO Projectruimte grant of 390,000 euro. He will use this budget to hire a postdoc and a PhD student to continue his research on flexibility of double stranded DNA.
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‘Unimportant’ plant gene turns out to be essential
Leiden biologists have shown that a gene present in plants, animals and yeasts does play an important role in plants, although for years the gene was considered unimportant. It turns out the gene plays a crucial role in the development of vascular tissue in plants. Publication in Nature Plants on 11…
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Student team invents Suckerspheres: sustainable alternative for microplastic
A Leiden Groningen student team has reached the European finals of the BISC-E competition. In this annual competition students have to come up with a sustainable solution to a major social problem. The team invented Suckerspheres: a natural alternative to the plastic microbeads that are still widely…
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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À la carte education
If you are interested in an academic programme, but do you not wish to complete the entire programme? Then, you can choose one of the many à la carte courses the Faculty of Humanities offers.
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Slice of Science
The first photo of a black hole and measuring anxiety in the brain... From 13 until 22 May we're serving a free slice of science with your pizza.
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ProParte Leesclub
The Reading Club is a sub-association of ProParte.
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MENA Cultures and Global Aesthetics
Aesthetic formations and cultural repertoires give meaning to our reality in ways that are never neutral. Focusing on the Middle East and North Africa (MENA) and its global interlocutors, this project brings together a team of scholars from Leiden University who bring in inter-disciplinary, inter-area…