Ariane Briegel has been appointed Professor in the fìeld of Ultrastructural Biology within the Faculty of Science at the Institute of Biology from the 1st of December 2015. Her expertise is in using electron cryotomography to study how microbes sense and respond to their environment.

Bacteria are everywhere. They are the most abundant organisms on earth and impact all aspects of our lives. They determine our health and shape our environment. Ariane Briegel, professor of Ultrastructural Biology, freezes bacteria super fast to gain a true-to-nature image of the internal and external…

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Are you thinking about studying Biology? Learn more and watch the videos.

This research programme aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services to facilitate strategic management of natural resources. To this end, we address urgent challenges in relation to the mechanisms involved…

Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

The bacterium Vibrio cholerae is a serious threat to our health because it is the causative agent of cholera. Worldwide, over a billion people per year are at risk of cholera infection. New strains of V. cholerae are resistant to the multiple drugs used to treat cholera, meaning that new types of drugs…

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Microbial Sciences' contribution to the Evolution & Biodiversity research theme focuses on understanding how bacteria sense and respond to their environment, and how bacterial diversity and evolution is influenced by cooperative and antagonistic interactions taking place between microbes.

The master’s programme Biology at Leiden University offers seven specialisations ranging from Cell Biology to Molecular Genetics. The programme prepares you for a career in research within or outside academia.

Biology is the study of life. Are you interested in understanding life, from the molecular level to entire ecosystems? Do you want to use your understanding and knowledge of biology to benefit the health of both humans and the environment? If so, Biology is the right study programme for you.

Microbial Sciences' contribution to the Host-Microbe Interactions research theme is to investigate how beneficial or disease-causing microbes associate and interact with their host.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Quantitative biology means exploiting mathematical modelling and computer simulation as a tool to gain additional insights into the meaning of experimental data. Discover in this minor when and how to apply these tools, in a multidisciplinary setting.

To address biological questions related to human health, chemical tools are essential. Covalent or non-covalent interactions of compounds with biomolecules offer a range of possibilities for study. They can be used to identify enzymes based on their activity, to influence cellular regulation, by changing…

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

The master’s specialisation Biology and Education at Leiden University prepares students to teach the subject of biology to secondary school students. The programme comprises a one-year Biology component, followed by an education component in the second year.

The master’s specialisation Evolutionary Biology at Leiden University investigates biology at all levels. The specialisation includes genomics, functional developmental genetics, paleobiology, behavioral biology and evolutionary ecology.

The Programme Committee Biology (Opleidingscommissie Biologie, OCB) consists of four teaching staff members and five students, and is assisted by the study adviser. The OCB has an independent position within the Biology education program. Because of its composition, the OCB is the most important organ…

The LED3 Network, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL) and the Leiden Academic Centre for Drug Research (LACDR), is very excited to organise the “LED3 Chemical Biology Talks”. This lecture series brings excellent researchers in…

Research on heredity and diseases is simply not possible without programmers. Curious about how you can use your IT and biology skills to deal with real-life sickness and health problems? If so, Bio-Informatics in Leiden could be something for you.

A thorough understanding of the workings of the cell underly the understanding of disease at the molecular level. Revealing the principles of biochemical processes helps to identify the targets for the development of new drugs. At the Leiden Institute of Chemistry (LIC), we believe that the application…

Nature is a never-ending source of inspiration for the researchers at the Institute of Biology Leiden (IBL). Based on a better fundamental understanding of nature, they are able to seek solutions in the area of health and biodiversity. The theme of IBL is ‘Harnessing biodiversity for health.’

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.

The master’s specialisation Biology and Business Studies at Leiden University bridges science and business development by focusing on areas such as technology management, innovation, entrepeneurship, operations, and decision making.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

This activity is currently not offered. An (online) alternative is being sought.

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Chemical biology research aims at understanding and manipulating biological processes at the molecular level. Physiological processes that are behind human disease are subject of detailed chemical biology studies with the aim to identify new drug targets, but also leads for drug development or that…

Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.

The master’s specialisation Biology and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in biology with extensive training in science communication.

The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.

How do bacteria sense and adapt to their environment? Ariane Briegel, Professor of Ultrastructural Biology, is intrigued by this question. Using new techniques, she produces three-dimensional images of bacteria that provide us with new clues about their sensory system.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Freezing bacteria super fast to gain a true-to-nature image of the internal and external structure. Ariane Briegel Professor of Ultrastructural Biology came to Leiden specially to carry out this research. Leiden University is one of the few institutes in the world to have the necessary equipment. Inaugural…

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Lezing

Mission: The Environmental Biology department aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services. Through this understanding they facilitate strategic management of natural resources by addressing urgent challenges…

Some examples of AI-research done at Leiden.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…