951 zoekresultaten voor “stress response pathways” in de Publieke website
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Novel role of the AT-HOOK MOTIF NUCLEAR LOCALIZED 15 gene in Arabidopsis meristem activity and longevity
Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Interstellar Catalysts and the PAH universe
Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.
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Singing is silver, hearing is gold: impacts of local FoxP1 knockdowns on auditory perception and gene expression in female zebra finches
The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Postdoc on Streptomyces development
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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Combatting Clostridioides difficile: stress, adaptation and antimicrobial resistance
Promotie
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and characterizing regulators of histone acylation and replication stress
Promotie
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Oxidative Stress in Chronic Diseases: Causal Inference from Observational Studies
Promotie
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SUMOylation in Proteostasis, Centromer Integrity and the DNA Damage Response
Promotie
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The Anti-Citrullinated Protein Antibody immune response and its effector functions in Rheumatoid Arthritis
Promotie
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Unravelling the anti-carbamylated protein antibody response in rheumatoid arthritis
Promotie
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Identification and characterization of novel factors in the DNA damage response
Promotie
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Dose-dependent and compound-specific phospho-signalling responses after (geno)toxic treatment
Promotie
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Impact of plant hormones on growth and development of actinobacteria
Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.
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General plant strategies and functions in wetlands: Global trait-based analyses
Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.
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Terug naar de opvang: kinderopvang in tijden van corona
In dit rapport worden de eerste resultaten van een vragenlijst onderzoek naar de ervaringen van ouders en kinderen tijdens de sluiting van kinderdagverblijven in de periode van 16 maart tot en met 11 mei 2020 besproken, evenals ervaring rondom de heropening van kinderdagverblijven.
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Understanding Al Qaeda in the Islamic Maghreb: responses to terrorist tactics and insurgent strategies
Promotie
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Metabolic signatures in nutrition and health: Short-term diet response, sexual dimorphism and hormone chronobiology
Promotie
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Promotie
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Anke Klein in NRC over het aanspreken van ouders van pesters
Moet je de ouders van de pesters van je kind aanspreken? Die vraag beantwoordt Anke Klein in de rubriek 'Opgevoed' van NRC. In deze rubriek worden lezersvragen elke week voorgelegd aan deskundigen. Haar advies? 'Laat je emoties eerst even bezinken.'
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PhD Candidate Governance of Crisis (part-time 0.5 fte)
Governance and Global Affairs, Institute of Security and Global Affairs
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Systemic and cerebral hemodynamics in response to cardiovascular challenges - the heart brain connection
Promotie
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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The role of the interleukin 12 family in atherosclerosis
Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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The rebound effect through industrial ecology’s eyes : the case of transport eco-innovation
Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)
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In de media en onderzoek
Hieronder vind je een overzicht van hoe onderzoekers van de faculteit Governance and Global Affairs en hun onderzoeken in de media verschijnen, en lees je meer over onderwerpen waar de faculteit zich mee bezighoudt.
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Peeking into the future: Fungi in the greening Arctic
Promotor: E.F. Smets, Co-promotor: J. Geml
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Large scale visual search
Promotor: J.N. Kok, Co-promotor: M.S. Lew
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
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Emergence of rebellious digital press in Chile: Divergence, engagement and impact. Journal of Communication
A new publication on changes in the relationship between news and their public in Chile
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From the root of variation: A metabolomics perspective to plant soil-feedback
By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Impact of land use changes on the human-elephant conflict
Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh
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Surviving embryogenesis: The extraembryonic serosa protects the insect egg against desiccation and infection
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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Onderwijs
De programmagroep Onderzoeksmethoden en statistiek verzorgt het overgrote deel van het methoden- en statistiekonderwijs in alle fasen van de opleiding Pedagogische Wetenschappen. Het programma van deze opleiding is gestoeld op een sterke empirisch-analytische traditie. Dat betekent dat onderzoeksmethoden…
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Microbial communities in Pampa soils; impact of land use changes, soil type and climatic conditions
Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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Bearing with noise: The effects of highway noise on behaviour and development in zebra finches
Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.