Psycholinguistic research

Measurement of brain activity by external electrodes (EEG).

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…

Quantitative biology means exploiting mathematical modelling and computer simulation as a tool to gain additional insights into the meaning of experimental data. Discover in this minor when and how to apply these tools, in a multidisciplinary setting.

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Brownian motion is the random motion of (colloidal) particles due to collisions with the atoms and molecules of the solvents, which are moving due to temperature.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Promotor: T. Schmidt

Is EEG theta\beta ratio predictive towards the negative effects of stress on cognitive performance in individuals suffering from performance anxiety? Can we improve resilience to performance anxiety by using a theta\beta ratio neurofeedback intervention?

Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

Fokelien Kootstra defended her thesis on 23 April 2019

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

This project aims to investigate the underlying (neurocognitive) linguistic processes of ellipsis resolution, particularly gapping.

The global population speaks approximately 7,000 different languages and approximately half of the world’s population is bilingual. The unique orthographic characteristics of different languages can help us to gain insight into the seemingly simple process of transforming written to spoken words (i.e.,…

The STW project Energy Efficient Computer-Brain Interaction (principal investigator for LIACS: dr. T.P. Stefanov) has been granted. Funding for LIACS: 1 PhD student + travel/equipment budget, project duration: 4 years.

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Research impact is measured in different ways. However, these indicators are often based on dubious calculations, says Ludo Waltman. Inaugural lecture on 21 June.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

Ludo Waltman has been appointed as professor of Science, Technology and Innovation Studies, especially Quantitative Science Studies, at Leiden University. The chair is located at the Centre for Science and Technology Studies (CWTS).

In this dissertation, electrophysiological (EEG) and behavioural measures are used to investigate how allophonic tonal variants and sub-phonemic features are processed during Mandarin and Dutch speech production, visual processing of written words and reading aloud.

Sebastian Diessner, associate professor at the FGGA, recently appeared in an article called 'Inflation: a spring remontée des taux se dessine' (Inflation: a slow rise in rates is emerging) in the newspaper Le Figaro.

During a meeting at the University on 10 November, staff spontaneously removed a painting by artist Rein Dool from the wall in one of the meeting rooms in the Academy Building, reversed it and placed it on the floor. A tongue-in-cheek action with a serious undertone. This has led to a lot of commotion…