The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Are there other planets like the earth, and will there also be life? Astronomers study planets around stars other than the sun, with the aim to find out what kind of gasses their atmospheres are made up with.

Promotor: J. A. Bouwstra

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Promotor: T. Schmidt

Lezing

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle).

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

A full overview of CASC PhD theses.

The master’s specialisation Research in Physics, Quantum Matter and Optics at Leiden University offers a thorough experience on the front line of physics research with a practical training of communicative and computer skills. The programme focuses on Condensed Matter problems, such as Molecular Electronics,…

Of the 97 Spinoza Prizes that have been awarded since 1995, 23 have gone to researchers from Leiden University. The NWO Spinoza Prize is the highest Dutch award in science. The younger NWO Stevin grant goes to researchers who have achieved great success in the field of knowledge utilisation for society.…

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

Dr. at Max Planck Institute for chemical Ecology, Jena - Germany

Can metabolomic profiling be used to predict resistance against insect herbivores in plants?

Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

FitDis! is designed to ease the determination of binding energy and oligomeric state of coiled coil peptides. It allows direct fitting of concentration dependent thermal peptide unfolding curves measured for instance by CD–spectroscopy.

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

Twee teams of astronomers, including from the universities of Amsterdam and Leiden, have discovered how hot gas giants are surrounded by large halos of thin helium gas, an indication that they are slowly losing their atmosphere. The helium, that was recently seen for the first time by the Hubble space…

Promotie

A full overview of BPOC/SSNMR PhD theses.

The Dutch-Japanese made DESHIMA instrument has passed its first practical tests when measuring the distances and ages of distant galaxies. The core of the instrument is a chip the size of two euro coins that measures 49 shades of far infrared light. The developers of the spectrometer publish the results…

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

Physics and Engineering Approaches to Biomedicine and Pharmacology

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

In our lab, we investigate the physics and material properties of low-dimensional systems.

At Leiden Observatory, researchers investigate the origin of stars and their planetary systems. They detect and characterize planets around other stars, which are called exo-planets. They study how stars and planets form. And they follow molecules from interstellar clouds to nascent planet systems.…

Coordination chemistry is the chemistry of metal atoms "coordinated" by other atoms, ions or molecules. Important challenges in the research on coordination and organometallic chemistry are to understand the relation between the ligand and metal complex structures and the (catalytic) properties of the…

Psycholinguistic research

Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:

Which metabolites of sponge are influenced by individual environmental or biological factors?

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Lezing

The Joan Van der Waals colloquium is an ongoing bi-weekly lecture series.

Rottgering

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Bead microrheology: Analysis of active and passive transport in living cells

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

These are the proposed research projects for LEAPS 2019. Please note that not all projects will go ahead and some may still be added in the near future. Final funding decisions lie with the Faculty sponsors. And please make a note that if you are interested in an ESA project, to check if your state…

Due to the corona pandemic the 12th International Metabolomics Workshop has been postponed. The event will not take place from March 30 to April 17 2020. We will inform you via this website as soon as we have a new date.

Kros

Koper

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)