2,014 zoekresultaten voor “spectral line identification” in de Publieke website
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DEEPSEA SOUND: pioneer explorations into biological relevance and anthropogenic disturbance
Are there acoustic cues for settlement stage larvae in deep-sea soundscapes around hydrothermal vents?
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LCN2 Seminar
Lezing
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Fault Lines: Design/ Research Symposium
Kunst en Cultuur, Symposium
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Discrete tomography for integer-valued functions
Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Promotie
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Image guided surgery: clinical validation of lesion identification technologies and exploration of nerve sparing approaches
Promotie
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Towards a better identification of child mental health problems in primary care
Promotie
- Accessibility
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Rapid and sensitive methods for the analysis and identification of O- glycans from glycoproteins
Promotie
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Identification of Therapeutic Targets and Antisense Oligonucleotide Mediated Exon Skipping Based Therapies in Arthritis
Promotie
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Identification of neural and non-neural contributors to joint stiffness in upper motor neuron disease
Promotie
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In search of Biomarkers for Leprosy Diagnosis: In silico identification, screening & field application
Promotie
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Grammar of Numerals And The Number Line
Lezing
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Mechanistic studies of the water oxidation reaction with molecular iron catalysts
In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.
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Natural Products Lab
We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.
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Archaeological Heritage Management
Archaeological heritage management is concerned with the identification, protection, management and preservation of the material remains of human activity in the past (of whatever period and in whichever region of the world) and with the interaction that this involves with all kinds of stakeholders.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Strategy
The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.
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Fast vaccine design and development based on correlates of protection (COPs) Influenza as a trendsetter
New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar
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NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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The Rome Statute as Evidence of Customary International Law
On 9 April 2019, Yudan Tan defended her thesis 'The Rome Statute as Evidence of Customary International Law'. The doctoral research was supervised by Prof. dr. W.A. Schabas.
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D-lightful Sunshine Disrupted
This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.
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Historic Chinese Materia Medica revisited
What are the differences between the trade in Chinese herbal drugs in Europe between 1800 and now? Can we see the major metabolic changes after 200 yours?
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Starchy foodways
Surveying Indigenous Peoples’ culinary practices prior to the advent of European invasions in the Greater Caribbean
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Rise and shine: the earliest red galaxies in the universe
Labbe
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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The link between hearing loss, language, and social functioning in childhood
The aim of this thesis was to study the link between hearing loss, language skills, and social functioning in deaf and hard of hearing (DHH) children. Sufficient language skills are an essential prerequisite to develop appropriate communication skills, in order to join in conversations with others.…
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Mining Sensor Data from Complex Systems
Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe
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Sybil-AA: Systems Biology of Alcohol Addiction
The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…
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Taking control of charge transfer: strategic design for solar cells
Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda
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Leiden Journal of Pottery Studies 21
Leiden Journal of Pottery Studies 21, 2005
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Opportunity and Problem in Context (OPiC). A framework for environmental management in developing countries
Promotor: W.T. de Groot
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The role of zebrafish (Danio rerio) larvae in developing new drug candidates for treating anxiety, from natural sources
Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?
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Evaluation of the environmental impact of products (EIPRO)
Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.
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Strategy
The division of Drug Discovery and Safety combines the former divisions Toxicology and Medicinal Chemistry.
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Key publications
Key publications of the Computational Drug Discovery group
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Hydrocarbons in interstellar ice analogues: UV-vis spectroscopy and VUV photochemistry
Promotor: Prof.dr. H.L.V. Linnartz
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A large-scale crop protection bioassay data set
ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace
On 10 June 2021, Merinda Stewart defended her thesis 'Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace'. The doctoral research was supervised by Prof. P.M.J. Mendes de Leon en Prof. J.J. Rijpma.
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Bio-informatics lab
On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…
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Prosody and processing of wh-in-situ questions in standard Persian
On April 4th, Zohreh Shiamizadeh succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Zohreh on this great result.
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The Case against Animal Rights: A Literary Intervention
This thesis aims at thinking through the ethical position of animals in a way that differs radically from the manner in which this ethical position is thought within contemporary animal rights discourse.
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Young Hae Choi
Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands
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Galactofuranose biosynthesis in the filamentous fungus Aspergillus niger
This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.