In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Promotor: S.M. Verduyn Lunel

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Promotor: Prof.dr. E. F. van Dishoeck

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Promotor: P.M. Brakefield

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotie

Including modelling as part of software development appears to have various benefits.

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Lezing

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Lezing, Studium Generale

Oratie

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotor: E.F. Smets Co-promotor: J. Geml

Promotor: G.R. de Snoo

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

How soil microbial composition impacts structure and composition of the aboveground plant and animal communities?

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

What invertebrates are available to feed nestlings in an agricultural landscape of varied complexity?

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Promotor: G.R. de Snoo, Co-promotor: C.J.M. Muster

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.