Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.

Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?

Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Kunst en Cultuur

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Promotie

Kunst en Cultuur

Kunst en Cultuur

Congres/symposium, Film screening

Lezing

Film screening

Lezing

A large, 64+ person space with multiple working zones in the Schouwburgstraat building, Den Haag. Tables fold and wheel, and chairs are also on wheels. There are multiple movable whiteboards which allow group working in various sizes. Windows and tables are additional writing surfaces. There is also…

Film Event

Film Screening

We like to welcome you kindly to the extract library of the Dutch Province of Zuid-Holland.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.

Promotie

Biological and behavioural measurements of parent-child interactions.

Kunst en Cultuur

Kunst en Cultuur

Congres/symposium

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Film and debate

Film and debate

Lezing, Studium Generale

The Protein Centre can supply you with purified proteins that are essential for many experiments, ranging from in vitro inhibitor screening and enzymatic analysis to manipulation of life cells.

Kunst en Cultuur

Kunst en Cultuur

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: M. Ubbink, Co-promotor: G. Siegal

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…

Shared, general-purpose labs.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Can new variants of daptomycin and the polymyxins be found?

The entrepreneurial spirit is highly present among the SBB students. The many (successful) spin-off companies from Leiden University brought by (former) SBB students are proof of this.

Kunst en Cultuur, Studium Generale | International Institute for Asian Studies

Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.

Our facilities cover:

Curious to know how studying in The Hague looks like? Take our VR tour through The Hague!

On Sunday evenings the NVIC is presenting NVICinema. We bring a varied programme of Dutch or Flemish films, Egyptian classics as well as contemporary Egyptian feature films and short films from young talented directors, all with English subtitles.

Promotie