1,922 zoekresultaten voor “pbpk modelling” in de Publieke website
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Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
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Metastability for low-temperature Kawasaki dynamics with two types of particles
Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi
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Onderwijs
Als groep verzorgen we ook onderwijs binnen het instituut Pedagogische Wetenschappen.
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Automatische detectie
Naast het speuren door vrijwilligers loopt er ook onderzoek naar de inzet van kunstmatige intelligentie bij de zoektocht naar onontdekte archeologische structuren.
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The Powers That Be
De afdeling Staats- en Bestuursrecht van de Universiteit Leiden heeft een bundel gepubliceerd over de vraag of de historisch gegroeide combinatie van de concepten van democratische legitimiteit en de scheiding van machten mogelijk blijft buiten de context van de traditionele staat, en indien dit mogelijk…
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Evolutionary diversification of Nepenthes (Nepenthaceae)
Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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Afdeling Industriële Ecologie (CML-IE)
The department of Industrial Ecology is dealing with research into the development of tools for decision making on sustainable production and consumption.
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Unraveling the surface formation of regular and deuterated water in space: a combined laboratory and computational study
Promotor: Prof.dr. H.V.J. Linnartz
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Hunting for new physics in the primordial Universe
This thesis contributes to studying primordial cosmology theories and their detectability in future observations.
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Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
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Agency van leerlingen in het voortgezet onderwijs: Hoe kunnen docenten de leeromgeving zo inrichten dat agency ruimte krijgt om te ontwikkelen
Agency van leerlingen wordt als een belangrijk onderwijsdoel gezien. In het onderwijs wordt agency gedefinieerd als het vermogen om in toenemende mate regie te nemen over het leerproces. Er is nog geen gedeeld inzicht in hoe agency zich ontwikkelt, hoe deze ontwikkeling gemonitord kan worden en wat…
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Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
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Voormalige projecten
Voormalige cliënten en projecten
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Programma Dual PhD Centre
Duaal promoveren Werken en promoveren Promoveren in deeltijd Promoveren naast je werk Buitenpromovendi Buitenpromovendus
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Voorspellen van medicijngedrag in de hersenen: van glazen bol naar wiskundig model
Lezing
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LCN2 Seminar: Dynamic random graph model for polymerisation in a confined environment
Lezing
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Begeleiding en beoordeling praktijk
De studieonderdelen die betrekking hebben op het functioneren van studenten in de onderwijspraktijk zijn Praktijk 1 (eerste deel van de opleiding) en Praktijk 2 (tweede deel van de opleiding).
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Instituut voor Informatica aan de Universiteit Leiden
Leiden Institute of Advanced Computer Science (LIACS)
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Macro-level assessment of environmental implications of changes to circularity
How to ensure the environmental and economic benefits of circularity transition at macro-scale?
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C-SCAPE - Sandy strategies for sustainable coastal climate change adaptation
What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?
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Onderzoek bij het Levend Lab
Wat doen bestrijdingsmiddelen, bemesting of plastic met de waterkwaliteit? En hoe beïnvloeden wind en regen de data? Dat en meer onderzoeken de Leidse milieuwetenschappers in de 32 sloten van het Levend Lab.
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Smart Industrial Parks in China: towards Joint Design and Institutionalization
How to contribute to a quantum leap of eco-industrial symbiosis in China?
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Marlies Reinders
Integratie van MOOC in campus
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epidemiologic methods on findings in studies of causal effects and prediction modelling
Promotie
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pathogenesis underlying bicuspid aortic valve disease using new disease models
Promotie
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Mixed models for correlated compositional data: applied to microbiome studies in Indonesia
Promotie
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
Promotie
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Characterization and re-evaluation of experimental pain models in healthy subjects
Promotie
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Controlled human infection models as a tool for malaria and schistosomiasis vaccine research
Promotie
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Experimental pain models for the evaluation of next-generation analgesics in clinical pharmacology studies
Promotie
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Beyond the Born-Oppenheimer Static Surface Model for Molecule- Surface Reactions
Promotie
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Patient derived zebrafish xenograft models for personalized treatment of uveal melanoma
Promotie
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Promotie
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
Promotie
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Advanced tools and methods for modeling cardiovascular disease using human pluripotent stem cells
Promotie
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In vitro models of bone-forming tumours: from target to treatment
Promotie
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The Retinal Crumbs Complex: From Animal Models and Retinal Organoids to Therapy
Promotie
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Plasmodium falciparum sporozoites in the controlled human malaria infection model
Promotie
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Promotie
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Fluorescent in vivo models for hematopoietic stem cell and lymphoid lineage analysis
Promotie
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underlying inflammation and infection control: insights from the zebrafish model
Promotie
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antiquity: From early modern reconstruction drawings to digital 3D models
Promotie
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Models of curves: The Birch and Swinnerton-Dyer conjecture & ordinary reduction
Promotie
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in human pluripotent stem cell derived cardiomyocytes for disease modelling and drug discovery
Promotie
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Accurate Modeling of the Dynamics of Dissociative Chemisorption on Metal Surfaces
Promotie
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Néron models in high dimension: nodal curves, Jacobians and tame base change
Promotie
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LCN2 Seminar: Network psychometrics: using network models to understand psychological constructs like personality, cognition, and mental illness
Lezing
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Promotie
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Seascape Corridors, Modeling Routes to Connect Communities Across the Caribbean Sea
Promotie