Brownian motion is the random motion of (colloidal) particles due to collisions with the atoms and molecules of the solvents, which are moving due to temperature.

Duality, stochastic processes

Our research primarily focuses on the early universe and its origins in theories that go beyond the Standard Model of particle physics.

This thesis discusses the discovery potential of Intensity Frontier experiments.

The miniaturization of machines towards the micron and nanoscale requires the development of joint-like elements that enable and constrain motion. We developed a facile method to create colloidal joints, that is, anisotropic colloidal particles functionalized with surface mobile DNA linkers that control…

A couple of years ago, theoretical physicist Carlo Beenakker tracked down the Majorana particles and inspired Leo Kouwenhoven from TU Delft to try to create them in a superconducting nano-structure. He succeeded in doing so in 2012, and the news made headlines around the world. But a lot of work still…

My work is motivated by the necessity to extend Standard Model of Particle Physics in order to explain three observed phenomena that this great theory fails to accommodate

In this research, for the first time a detailed description as well as systematic and comparative analysis of the final particle system in Chinese are provided.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

This study explores regional variation in the use of utterance-final particles by analyzing spoken Taiwan Mandarin data recorded from spontaneous conversations.

Light obscuration (LO) is the current standard technique for subvisible particle analysis in the quality control of parenterally administered drugs, including therapeutic proteins.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

This handbook provides a resource for those already familiar with some kinds of micro-particles who wish to learn more about others, or for those just starting out in the study of microremains who wish to have a broad understanding about microscopic archaeology.

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

Theoretical physicists research a special class of particles; Weyl fermions. They have found them to exhibit paradoxical behavior, in contradiction to a thirty-year old fundamental theory in electromagnetism. A possible application is a new kind of electronics—spintronics. Publication in Physical Review…

In this dissertation, the types of context Dutch speakers need to interpret the poly-interpretable word ergens ‘somewhere/anywhere’ are studied.

Leiden researchers have carried out successful tests using a new method of packaging a cancer vaccine in nano-particles. The new vaccine has induced a strong immune reaction in mice. The researchers believe that this method can make an important contribution to the treatment of cancer. Their findings…

Materials are either gas, liquid or solid, based on how their molecules respond to temperature and pressure. But what if the building blocks are self-spinning particles instead of ordinary molecules? Theoretical physicists found out what determines the phase of those artificial materials. Publication…

In Leiden, light particles march into Wolfgang Löffler’s experiments one by one. His research focuses on acquiring the fundamental knowledge needed to develop quantum computers and networks.

Gold nanoparticles give us a better understanding of enzymes and other molecules. Biswajit Pradhan, PhD candidate at the Leiden Institute of Physics, uses gold nanorods to study individual molecules that would be challenging to detect otherwise. Resulting knowledge can be applied to many research fields,…

Are Weyl particles the ideal conductors? Do cells without a cell wall play a role in chronic Tuberculosis infections? Carlo Beenakker and Dennis Claessen want to answer these questions. They both received a KLEIN grant from the NWO. With these grants, NWO wants to stimulate innovative, fundamental r…

Promotor: Prof.dr. H.J.A. Rottgering, Co-promotor: David Sobral

Promotor: Prof.dr. M.L. van Hecke

Promotor: W.Th.F. den Hollander

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

While colloidal aggregates are often undesirable due to their random shapes, we exploit them as a starting point to synthesize patchy particles.

Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.

Multi-Angle Dynamic Light Scattering (MADLS) is a technique that is used to determine properties of particles in suspension. The measurements give the hydrodynamic size distribution of individual particles as well as particle clusters, and assists in the interpretation of the stability of the particles…

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Microscopic spheres that can self-propel through a liquid move faster over a hydrophobic surface than they do over a hydrophilic surface. ‘This was a surprise,’ says Stefania Ketzetzi, the researcher who discovered the effect. Understanding how these artificial spheres move is important for understanding…

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

Promotie

Lezing

How do nanoparticles bioaccumulate and biodistribute in organisms?

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).