It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Optimality in plant properties and processing.

The focus of the Multicriteria Optimization and Decision Analysis (MODA) group is to develop foundations of methods in multi-objective optimization.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

This dissertation provides crucial but as yet missing empirical data on the tone accent opposition in the so-called

This dissertation provides a formal description of the relationship between diatopic/diachronic micro-variation and phonologization through analysis of the phonetic/phonological properties of unstressed vowel reduction and vowel insertion in two Northern Italian dialects.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotor: Prof.dr. H.A.G. Wijshoff

Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.

Edited by linguists Jenny Audring (Leiden University) and Francesca Masini (University of Bologna), this is a unique handbook with a focus on morphology theories rather than morphological data. It covers a wide array of morphological theories, from traditional twentieth century models to current theoretical…

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

The research programme Probability Theory focuses on probability theory and on operations research.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Promotie

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

The better teaching is for pupils and students, the more solid the basis will be that we give them for their future careers. This type of teaching requires strong instructors and insight into the best ways in which pupils can be supported, and research at Leiden University is making a contribution in…

The currently available in vitro generated human skin equivalents resemble the human skin in many aspects. However, some essential barrier characteristics do not fully mimic the native barrier. Consequently, the human skin equivalents cannot be used for screening of drugs for skin penetration.

Development of scenarios for 2050 detailed in an IO framework

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

This thesis is based on five papers on several topics.

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Multi-objective optimization is an effective technique for finding optimal solutions that balance several conflicting objectives. It has been applied in many fields of our world, because practical problems usually have more than one desired goal. For example, developing a new vehicle component might…

Online Convex Optimization for the Effective Curvature

Bruin

The research of the Algebra, Geometry and Number Theory programme ranges from fundamental mathematical theory to algorithms and applications.

This thesis investigates durational aspects of the Italian mobile diphthongs with respect to other rising diphthongs and monophthongs and it shows to what extent the monophthong/diphthong alternation still occurs in contemporary Italian.

This book addresses the definition of history and how people are influenced by it.

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

The SAPPAO project aims to optimise the accuracy and reliability of predicting scheduled flight times. The full name of the project is 'A Systems Approach towards Data Mining and Prediction in Airlines Operations'.

Promotor: H.W. Lenstra, Jr., Co-promotor: B. de Smit

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

Subproject of

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Promotor: E.F.A. Deprettere, Co-Promotor: A.C.J. Kienhuis

Although exposure therapy is the gold-standard treatment of posttraumatic stress-disorder (PTSD), only half of the patients adequately benefit from it. Based on recent insights into the mechanisms of extinction, this project examines strategies and techniques to improve exposure treatment outcome in…

The research of the Algebra, Geometry and Number Theory cluster tries to bridge the gap between abstract theory and the world of algorithms and applications.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

The Death of Archaeological Theory, edited by John Bintliff and Mark Pearce, addresses the provocative subject of whether it is time to discount the burden of somewhat dogmatic theory and ideology that has built up over the last 25 years.

Developing a method to simplify polynomials in complex curves

Majorana meets a mermaid

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

Promotor: S.M. Verduyn Lunel