Multicellular giant algae Chara species have been widely used in physiological studies for decades.

How can the transport of molecules in living cells help to target medicines at exactly the right place?

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

Promotores: H. Schiessel, G.T. Barkema

Promotor: Prof.dr. M.K. Richardson

Marta Fiocco, associate professor at the Mathematical Institute of Leiden University, has signed an agreement with the UWV (the administrative authority that implements employee insurances and provides labour market and data services) to work with their data in the research project

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…

What are the capabilities or limitations of traveling between islands and how does this reflect seasonal variation? Is it possible to show higher levels of connectivity between islands based on generated pathways between several sites on two separate islands?

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How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

This thesis describes the use of the evolutionary approach in the study of language change, aiming to provide a better insight in the mechanisms that play a role in language change and to validate this approach in the field of language change.

Assessing the feasibility and legitimacy of the current model of global tax governance and the role of the OECD and EU in international tax law-making.

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Many students have difficulties to read and give meaning to algebraic formulas. In this study it is explored whether graphing formulas with pen and paper will improve students’ability to reason with algebraic formulas.

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

With dismay we took note of the sudden death of Willem Obbens, student and student assistant in Mathematics, Leiden University.

Mathematics students Bob Zwetsloot, Daan Becker, Loek Veenendaal and Onno Berrevoets have won 3 medals during the International Mathematics Competition in Blagoevgrad, Bulgaria last week.

The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

We consider the propagation of electrical signals through nerve fibres.

Anja Rüten-Budde is our Mathematical Institute’s nominee for the C.J. Kok Jury Award 2020.

Professor of number theory Peter Stevenhagen has been appointed to up the position of scientific director of the Mathematical Institute of Leiden University on 15 September. In this position he is the successor of Aad van der Vaart, who led the institute for the last four years.

René Pannekoek received the 2013 Philipsprize for PhD students in Mathematics at the Dutch Congress for Mathematics 2013 in Nijmegen. It was the 8th time that this prize, 1000 Euro and a trophy, was awarded.

During the Dutch Mathematical Congress, Joost Batenburg has been awarded the Philips Mathematics Prize for PhD students.

On January 5, Rosa Winter will obtain her doctorate in arithmetic geometry. She researched solutions of equations that define so-called ‘del Pezzo surfaces’. ‘I like geometry because I can imagine and draw the shapes and objects,’ says Winter. ‘That makes abstract mathematics feel more tangible.’

Promotor: S.M. Verduyn Lunel

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

In cryptography, the sky is the limit according to the new professor Mathematical Cryptology Léo Ducas. He already designed several cryptosystems as part of his research at the Centrum Wiskunde & Informatica (CWI), some of which might soon be adopted as new international standards. Since December,…