Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

In this dissertation, Boethius’ mathematics and logic and their roles in philosophy are reassessed, and on the basis of these, the connections between mathematics and logic in Boethius and their applications to theological or philosophical topics are explored.

PhD student Robbin Bastiaansen applies mathematics to get insight in practical problems. By comparing mathematical models with developments in existing ecosystems, he hopes to demystify the process of desertification. His research has been published in Proceedings of the National Academy of Sciences…

Each year, poppies disperse seeds that grow into a new generation of flowers. Sometimes, some of the seeds postpone their germination for a few years, for example when they’re covered by a layer of sand. Only when the sand disappears, do they start to sprout. Margriet Oomen did mathematical research…

Kunst en vrije tijd, Kunst en vrije tijd

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Towards a framework that integrates content-based and process-based accounts of mathematical thinking

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Peter Grunwald

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

ASLU 14

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

The number of mathematics students in higher education is increasing spectacularly. This year, the influx of new students rises to more than 1000 on a national scale. This is a fivefold increase compared to the number of students that registered for an education in Mathematics in 2002.

A research agenda

In this research project child language phonology is studied from the perspective of a psycholinguistic speech-production model and this model is in turn studied from the perspective of developmental phonology.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Are predictive archaeological maps a reliable tool to play an important role in the spatial planning? One of the goals of this project was to develop best practices for the production and application of the models.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

Lezing

The Plant BioDynamics Lab (PBDL) is a laboratory dedicated to experiments designed to develop and validate quantitative mathematical models of dynamical processes in biology. The principal objective of developing these models is to make quantitative predictions about these processes.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Lezing

The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.

Promotor: Prof.dr. J.N. Kok

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

The Minor in Teaching was introduced in 2009 as a new initiative to introduce and prepare bachelor students for teaching. Student numbers are low, however, especially of mathematics and science students.

Promotie

Promotor: Prof. dr. A.G.G.M. Tielens