What impact does a mid-season wildfire have on grassland invertebrates?

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: Prof.dr. M.K. Richardson

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.

New digital methods and a data explosion are radically changing archaeological research. Karsten Lambers, Associate Professor of Archaeological Computer Science, tells us all about it.

Henrik Barmentlo is our Institute of Environmental Sciences' nominee for the C.J. Kok Jury Award 2020.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?

We aim to keep experiments on animal to a minimum. We therefore assess every study whether full account has been taken to implement the 3 Rs: replace, reduce, refine. The Animal Welfare Body advises researchers on this. By training our staff and provide further courses, we are able to continuously…

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What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

This thesis combines field and laboratory studies to address some of the most pressing questions in the field of microplastic research.

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

What is the best method and time to test the effectiveness of medicines? PhD student Rob van Wijk of the Leiden Academic Centre for Drug Research (LACDR) discovered zebrafish larvae are best used in drug research when they are five days old. His findings were published on 15 February in the journal…

Are there acoustic cues for settlement stage larvae in deep-sea soundscapes around hydrothermal vents?

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

What are the risks of nanoparticles?

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

On Monday 21 September Annemarie Meijer, Professor of Immunobiology, presented her inaugural lecture on immunobiology and infectious disease.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Promotor: G.R. de Snoo

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Promotors: Prof.dr. P.G.L. Klinkhamer, Prof.dr. P.M. Brakefield

The objective of this study is to better understand the distribution of microplastics in the environment. More specifically, we will quantify the abundance and distribution of microplastics on beaches.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Bacteria are everywhere. They are the most abundant organisms on earth and impact all aspects of our lives. They determine our health and shape our environment. Ariane Briegel, professor of Ultrastructural Biology, freezes bacteria super fast to gain a true-to-nature image of the internal and external…

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

In this thesis, we present new laboratory data of interstellar dust analogues.

Playing a musical instrument is generally considered to be a complex human behaviour involving the integration and coordination of a broad range of human functions such as perception, imagination, memory, information processing, emotion, communication, and dexterity.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

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