586 zoekresultaten voor “innate immunity” in de Publieke website
-
Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax
-
Key innate immune components controlling intracellular infection
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
-
Innate immune defence against intracellular pathogens
What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?
-
Inaugural lecture: Innate immunity into the picture
Tuberculosis bacteria and other intracellular pathogens use cells of our immune system as Trojan horses to spread into tissues. Annemarie Meijer, professor of immunobiology, explains how research into innate defence mechanisms using zebrafish inspires novel strategies for infectious disease treatmen…
-
Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
-
glucocorticoid and mineralocorticoid receptor signaling in the innate immune system
Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?
-
Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
-
Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
-
The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf
-
Engineering innate immunity for therapy
Immune system defends our body against pathogens and cancerous cells, but excessive immunity can in turn lead to tissue damages and diseases. For example, scratching the surface of the eye ignites an immune response that aims at preventing infection but can also lead to edema, angiogenesis and eventually…
-
New light on innate plant immunity
Plants are able to resist a pathogen’s attack by a dual innate immune system. The relationship between the two pathways was not clear, but it turns out that they mutually potentiate each other, as assistant professor Pingtao Ding (Institute of Biology Leiden) and colleagues (The Sainsbury Laboratory,…
-
Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
-
Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
-
metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
-
Glucocorticoid modulation of the immune response
Unraveling the immune-suppressive actions of drugs like prednisone.
-
Patrick van Hage
Wiskunde en Natuurwetenschappen
-
Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
-
Maurijn van der Zee
Wiskunde en Natuurwetenschappen
-
Annemarie Meijer
Wiskunde en Natuurwetenschappen
-
The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
-
Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.
-
Herman Spaink
Wiskunde en Natuurwetenschappen
-
Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection
Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.
-
Zwitterionic oligosaccharides: charging the immune system
How are carbohydrates processed by the immune system? Can carbohydrates be used to trigger T-cells against other conjugated antigens? Can they be used as adjuvants?
-
The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
-
ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
-
Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
-
Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
-
Towards controlled microneedle-mediated intradermal immunization
Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.
-
Immunity, Infection and Tolerance
The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.
-
Immunity, Infection and Tolerance
Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…
-
Aging and Immunity
The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.
-
Immune Activation and Tolerance
The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…
-
Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
-
Live or let die: the intracellular fate of pathogenic mycobacteria
How do mycobacteria subvert the defenses of host immune cells?
-
Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
-
Nitric oxide in defence against mycobacterial infection
Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?
-
TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge
TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.
-
Characterization of innate immune cells in the glioma microenvironment
Promotie
-
Characterization of innate immune cells in the glioma microenvironment
Promotie
-
Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
-
Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
-
Inflammafish: Cross-talk between inflammation and autophagy in tuberculosis
Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.
-
Stromal cells suppress immune response symptoms
A new therapy for the serious Graft-versus-Host disease
-
Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?
-
PhD candidate in Molecular Plant Immunity
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
-
Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager
-
Auto/Immunity – Art Strategies Against a Military Sense of Self
To what extent and in what manner can experimental video be used to reclaim the capacity for telling one’s own story, on one's own terms, speaking in tongues outside the linguistic framework of immune system discourse?
-
The immune system in action against cervical cancer
In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.
-
Resetting the immune system to cure diabetes and rheumatism
In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.