Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Promotor: M. Ubbink, Co-promotor: G. Siegal

Supervisor: Gerard van Westen

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.

Promotor: A.P. IJzerman

Promotor: A.P. IJzerman

On Wednesday 5 June, Kalin Anev Janse, Secretary-General and Management Board Member of the European Stability Mechanism (ESM), was invited to give a lecture on 'Bridging decision-making: a new direction for Europe? Prioritising financial stability: the European Stability Mechanism and the Banking U…

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Promotor: A.P. IJzerman

On Thursday 2 May, the Institute of Security and Global Affairs (ISGA) of Leiden University hosted a guest lecture given by former NATO Assistant Secretary General for Emerging Security Challenges, Ambassador Sorin Ducaru.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

During the course of drug discovery translational steps are made.

Source: Purinergic Signal., Volume 10, Issue 3, pp. 441-53 (2014)

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Publication by: Anouk Wezel, Sabine Welten, Wida Razawy, Max Lagraauw, Margreet de Vries, Eveline Goossens, Martin Boonstra, Jaap Hamming, Ekambar Kandimalla, Johan Kuiper, Paul Quax, Yaël Nossent and Ilze Bot. Annals of Surgery. 2015;262:841-848.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Getting personal

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…

Supervisor: Indira Nederpelt

Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’

The mission in this research group, headed by Ad IJzerman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

Supervisor: Lizi Xia

Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)

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This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

We consider the propagation of electrical signals through nerve fibres.

Promotor: W. Jiskoot, Co-promotor: H.A. Every