Duality, stochastic processes

We study the physics of a broad range of biological and soft materials

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

This interdisciplinary research project explores several adaptive machine learning methods which can give insight into the interaction between human and machine. The ultimate goal is open and natural communication between humans and AI that should result in mutual trust, cooperation and coordination…

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Research into research improves the academic system. CWTS studies and evaluates the academic system in various ways. One way is to provide information on the productivity and impact of academics by documenting how many publications they or their universities produce and how often these publications…

An important hormone excreting gland in the human body is the pituitary

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Dishoeck

How are carbohydrates processed by the immune system? Can carbohydrates be used to trigger T-cells against other conjugated antigens? Can they be used as adjuvants?

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: S.M. Verduyn Lunel

The experimental approach of science applied to artistic research

On 29 January 2019, Robbert van Eijk defended his thesis 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. The doctoral research was supervised by Prof. dr. H.J. van den Herik.

Promotie

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

How can we explain that Caribbean small states have the most stable two-party systems in the world, while Pacific small states have either very weak parties or no parties at all? Matthew Louis Bishop (University of Sheffield, UK), Jack Corbett (University of Southampton, UK) and Wouter Veenendaal (Leiden…

Promotores: W. Jiskoot, F. Ossendorp

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In this article, published on the website SAGE research methods, authors Jaroslaw Kantorowicz and Tobias M. Hlobil discuss how a Regression Discontinuity Design can be executed.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Pathways of toxicity

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

Promotor: Prof.dr. J. Kuiper

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

Knowledge and culture subproject 2: "Language and number" of Leiden University Centre for Linguistics

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

The first objective is to create a catalogue raisonée, i.e. a structured database that will store the main attributes of each town in a standardized format database, which will be freely accessible when completed; the second objective is to exploit theories and methods that can help us to understand…

On 25 January 2018 Yannick van den Brink defended his doctoral thesis titled ‘Voorlopige hechtenis in het Nederlands jeugdstrafrecht’ (‘Pre-trial detention in the Dutch juvenile justice system’). The doctoral research is supervised by Professor Ton Liefaard and Professor Mariëlle Bruning.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

Promotor: Prof.dr. M. Ubbink

The major aim is to unravel the central mechanisms of how peoples’ expectancies affect physical symptoms, immune and endocrine responses, and related health outcomes, through the use of pioneering multidisciplinary methods in experimental studies in healthy and clinical populations.

Intelligence of the crowd, or in other words, intelligence of a large, random collective, exists mostly in social media platforms such as twitter. The collective does not comprise (at least not necessarily) experts on crises, just regular people mostly. Nevertheless, there is valuable intelligence to…