We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Promotores: Wim Jiskoot; Ferry Ossendorp

Promotor: Prof.dr. W. Jiskoot, Co-promotor: A. Kros

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotie

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

Development & Disease is one of the four research themes of the Institute of Biology Leiden.

The potential of liposomal cancer vaccines

Overkleeft

Promotie

Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

Promotor: B. van de Water

A critical look at the impact assessment modelling of metals in Life Cycle Impact Assessment and improvement options.

Key publications of the Biologics Formulation group

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

Case Studies in Etruscan Ritual Behaviour

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

How to improve the method in quantifying the combined effects of metal-based chemicals?

Thomas Hansen is the recipient of the 2021 KNCV-Backer Prize for best organic chemistry thesis in the Netherlands.

Thomas Hansen is the recipient of the 2020 KNCV-Backer Prize for best organic chemistry thesis in the Netherlands.

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

Majuka Tanabe defended her thesis on 17 June 2015

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

If you could convert CO2 into building blocks for other molecules with the help of electricity, you could make the chemical industry considerably more sustainable. Leiden chemists have unravelled a fundamental part of this process and applied this knowledge in a real device, as they write in Nature…

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

Dr. Amanda Foks obtained a fellowship from the dr. E. Dekker-program for the project ' Can promotion of efferocytosis induce regression of atherosclerosis?', in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research…

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

Lezing

Lezing