Wangyang Fu

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Onderzoeksgroepen in het Biological & Soft Matter onderzoeksprogramma ontrafelen de mechanismen in biologische processen en ontwikkelen nieuwe zachte materialen die geïnspireerd zijn door de natuur.

Schneider

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

In deze master specialisatie ligt de focus op het begrijpen van biologische processen in hun natuurlijke context, zoals cellen en weefsels.

How do nanoparticles bioaccumulate and biodistribute in organisms?

Promotores: H. Schiessel, G.T. Barkema

What is vegetation structure and composition in SFM primary forest, secondary logged over forest (logging FSC certified and logging non certified) in comparison to primary forest? What is avian guild diversity in SFM primary forest, secondary logged over forest (logging FSC certified and logging non…

Description of The Regional Network on the Synergy between the Convention on Biological Diversity and the UN Convention to Combat Desertification.

Het artikel gaat over de fysiologische herkenning van daderkennis en of dit ook gebruikt van worden om ware van valse bekentenissen te onderscheiden.

Donderdag 2 Februari 2017 heeft Prof. dr. Janne Bengtsson van de 'Swedish University of Agricultural Sciences' in Uppsala een lezing gegeven met de titel:

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Oratie

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotie

Promotie

Mechanical interactions between cells and their environment play an important role in many biological processes.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Promotor: A. Kros

Promotor: Prof.dr. J.N. Kok

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Promovenda Jiangnan Ding onderzoekt hoe je een blok rubber zo kunt ontwerpen dat het dienst kan doen als een mechanische computerbit. Zo'n zogenaamd mechanisch metamateriaal wordt op een specifieke manier samengeperst om de vorm te veranderen. ‘Met een heel eenvoudig materiaal kunnen we in de toekomst…

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Promotor: Prof.dr. T. Hankemeier

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

Kleinere computerchips, smallere cameraatjes; ze worden steeds moeilijker om te maken. Maar wat als de bouwstenen zichzelf opbouwen? Natuurkundige Daniela Kraft bedacht een methode om deeltjes aan te sturen in samenklonteren. Publicatie in ACS Nano.