Universiteit Leiden

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Postdoc candidate in biochemistry / cell glycobiology / protein targeted degradation

Wetenschappelijke functies
Omvang (fte)
Geplaatst op
9 maart 2022
18 maart 2022 Vacature gesloten

The Faculty of Science and Leiden Institute of Chemistry are looking for a:
Postdoc candidate in biochemistry / cell glycobiology / protein targeted degradation
Vacancy number: 22-154

Key responsibilities
Targeting glycosyltransferases, the enzymes responsible for glycan synthesis, holds great potential for the development of drugs for a variety of diseases. The Leiden Institute of Chemistry specializes in the discovery and development of glycosyltransferase inhibitors and probes. For these new biochemical assays are developed and the biological validation of such inhibitors are performed in vitro, in cells and in vivo. Recently, the team is also investigating targeted protein degradation of carbohydrate processing enzymes enabling proteins previously considered ‘undruggable’ to be downregulated. 
The post-doctoral researcher we are looking for will help developing biochemical assays and assessing the biological activity potential glycosyltransferase inhibitors and degraders, together with (PhD) students and postdoctoral researchers working on a variety of drug development programs related to glycobiology. The candidate is thus an experienced biochemist with experience in molecular/cell biology research and affinity for, or an interest in, protein targeted degradation and chemical glycobiology research.

Selection Criteria
•    PhD-degree in analytical biochemistry, cell biology, medicinal chemistry or equivalent;
•    Proven experience for biochemistry, cell biology, mass spectrometry and/or drug discovery;
•    Interest in chemical glycobiology and protein targeted degradation research;
•    Biochemical lab skills including cell culture, protein expression and purification, immunohistochemistry, and flow cytometry;
•    Proficient in English;
•    Excellent communication skills;
•    Ability to work independently and as a team player in a multidisciplinary environment.

Our organisation
The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future. 
The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organized in eight institutes. These institutes offer eight bachelor’s and twelve master’s programs. The faculty has grown strongly in recent years and now has more than 2,300 staff and almost 5,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together. For more information, see https://www.universiteitleiden.nl/en/science 
The chemistry and life science research in the Leiden Institute of Chemistry (LIC) is organized around two major research areas: ‘Chemical Biology’ and ‘Energy & Sustainability’. Our environment and quality of life is largely determined by chemistry, therefore research at the forefront of molecular and the life sciences is of utmost importance for our future. For example, the next generation of solar cells or batteries, and the improvement of existing as well as the development of new drugs rely on smart chemical solutions. Knowledge of catalysis, synthesis and biological processes on molecular scale will enable us to discover novel processes and products that range from new materials to pharmaceuticals. 
The institute’s research themes illustrate the central position of chemistry between biology, medicine and physics. The various research topics carried out within these themes are ideal for executing interdisciplinary research.

Terms and conditions
We offer a temporary position, initially for one year and with the option to extend for another two years based on good performance. Salary ranges from € 3,420 to € 4,490 gross per month based on a full time (1.0 fte) employment, (pay scale 10 in accordance with the Collective Labour Agreement for Dutch Universities).
Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3%), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Enquiries can be made to Prof. Herman Overkleeft (h.s.overkleeft@chem.leidenuniv.nl) and Dr. Marta Artola (m.e.artola@lic.leidenuniv.nl). Information about the Leiden Institute of Chemistry can be found at https://lic.leidenuniv.nl/  and about Leiden University at https://workingat.leiden.edu/ .

To apply for this vacancy, please send an email to the secretariat Mrs. Jessica van Krimpen, e-mail: j.e.van.krimpen@lic.leidenuniv.nl. Please ensure that you upload the following additional documents quoting the vacancy number:
•    Letter of motivation addressed to Prof. Herman Overkleeft and Dr. Marta Artola, including a statement why you are suited for this position;
•    Curriculum vitae;
•    Three references, including names, affiliations and email addresses.
Only applications received no later than March 18th, 2022 can be considered

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