Universiteit Leiden

nl en


PhD candidate, to create paramagnetic NMR probes to study protein dynamics

Omvang (fte)
Geplaatst op
06 oktober 2020
01 december 2020

Nog 37 dagen om te solliciteren

The Faculty of Science and the Leiden Institute of Chemistry are looking for a

PhD candidate, to create paramagnetic NMR probes to study protein dynamics

Project description
Modern NMR spectroscopy can be used to study minor states of proteins that are important for function (relaxation dispersion NMR). This method could become much more powerful when married to paramagnetic NMR methods, having a major impact on the study of protein dynamics. The PhD student will carry out research leading to a PhD degree, and will design and synthesize conformationally restricted paramagnetic metal complexes, determine their conformations, tag proteins, and demonstrate their application in relaxation dispersion NMR spectroscopy. The PhD student must be flexible and communicative and able to work in both (in)organic and biochemistry labs and learn advanced protein NMR methods.

Selection criteria

  • Master degree in (in)organic chemistry, or equivalent;
  • Proven interest in NMR spectroscopy;  
  • Proven interest in protein structure and function;            
  • Proficient in English;
  • Excellent communication skills.

Our organisation
The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. Our people are driven by curiosity to expand fundamental knowledge and to look beyond the borders of their own discipline. The research carried out at the Faculty of Science is diverse, ranging from mathematics, artificial intelligence, computer science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The faculty has grown strongly in recent years and now has more than 2,300 staff and almost 5,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together. For more information, see the website of the Faculty of Science.

The Leiden Institute of Chemistry (LIC) is organized around two major research areas: ‘Chemical Biology’ and ‘Energy & Sustainability’. The institute’s research themes illustrate the central position of chemistry between biology, medicine and physics. The various research topics carried out within these themes are ideal for executing interdisciplinary research.

Terms and conditions 
We offer a full-time position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary range from 2.395,-  to € 3.061,- gross per month (pay scale P, in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break. For more information, see the website.

All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Enquiries can be made Mark Overhand, email m.overhand@chem.leidenuniv.nl or Marcellus Ubbink, email m.ubbink@chem.leidenuniv.nl.

To apply for this vacancy, please send an email to Ingrid Bekooy, e-mail bekooy_i@lic.leidenuniv.nl. Please ensure that you upload the following additional documents quoting the vacancy number:

  • Letter of motivation addressed to Marcellus Ubbink, including a statement why you are suited for this position;
  • Curriculum vitae;
  • Transcripts of bachelor and master curriculum courses, including grades;
  • Three references, including names, affiliations and email addresses.

Only applications received no later than 1 December, 2020 can be considered.


Deze website maakt gebruik van cookies.  Meer informatie.