Universiteit Leiden

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Assistant Professor Quantitative systems biology of (adverse) drug responses

Wetenschappelijke functies
Omvang (fte)
Geplaatst op
14 mei 2019
20 juni 2019

Nog 25 dagen om te solliciteren

The Faculty of Science and the Division Drug Discovery and Safety of LACDR is looking for a

Assistant Professor Quantitative systems biology of (adverse) drug responses

Key responsibilities
The division of Drug Discovery and Safety applies high throughput screening in combination with quantitative systems biology approaches to understand the dynamics of cellular responses in relation to drug action related to anticancer therapy as well as adverse drug reactions. We apply high content imaging to determine the dynamic activity of individual signalling events at single cell level in 2D and 3D models. High throughput transcriptomics is used to determine signalling pathway activation and distinguish pharmacological and toxicological mode of action as well as human variability. RNA interference screens, pharmacological modulation and genetic engineering approaches are applied to uncover functional roles of candidate modulators of drug outcome. The work is related to understanding of cancer progression and drug resistance as well as adverse drug reactions related to liver and kidney injury. The investigations are part of (inter)national research programs.

The assistant professor will scientifically contribute to the above research in the division and develop bioinformatics tools and approaches for data acquisition, management and analysis as well as support and guide both undergraduate and graduate students with their bioinformatics work. The assistant professor should contribute to the acquisition of research grants. The candidate will also actively contribute to the BSc and MSc program of Bio-Pharmaceutical Sciences, involving the coordination of teaching modules and supervision of internship research projects.

Selection criteria

  • A PhD in bioinformatics, systems biology or relevant bio-medical sciences background;
  • Several years post-doc experience are preferred;
  • Enthusiastic and ambitious;
  • Independent thinker;
  • Expertise in ‘big data’ and fluent in bioinformatics programming languages, with focus on R
  • Excellence in teaching and experience in course development;
  • Excellent scientific writing skills;
  • Ideal soft skills to supervise undergraduate and graduate students;
  • Preferred background in biological questions related to anticancer therapy and/or adverse drug reactions;
  • Strong team player.

Research at our Faculty/Institute
The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future.

The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organized in eight institutes. These institutes offer eight bachelor’s and twelve master’s programmes. The faculty has grown strongly in recent years and now has more than 1,300 staff and almost 4,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together. 

The Leiden Academic Centre for Drug Research (LACDR) is a leading institute dedicated to world-class research and education in drug discovery and development. LACDR comprises a diverse and international team of approximately 150 researchers.

Terms and conditions 
We offer a full-time, 1 year term position, with the possibility of 3 year  renewal based on need, funding and performance. Salary range from € 3.637,-  to  € 4.978,-  gross per month (pay scale 11 in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses(8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break.

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Leiden University requires teaching staff to obtain the University Teaching Qualification (UTQ). If the successful applicant does not already  possess this qualification or its equivalent, he/ she must be willing to obtain this Qualification within two years., There’s a language proficiency of minimum level Cl required  for staff who will teach in English.

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Enquiries can be made to professor Bob van de Water (b.water@lacdr.leidenuniv.nl; +31-71-5276223). If you have any questions about the procedure, please contact the secretariat of the Division of Toxicology, Anneke Poels (secretariaattox@lacdr.leidenuniv.nl); +31-71-5276270). Information about the faculty of science can be found at  https://www.universiteitleiden.nl/en/working-at

To apply for this vacancy, please send an email to professor Bob van de Water (b.water@lacdr.leidenuniv.nl) and the secretariat, Anneke Poels (secretariaattox@lacdr.leidenuniv.nl). Please ensure that you upload the following additional documents quoting the vacancy number:

  • Motivation letter;
  • Curriculum Vitae;
  • 2 reference letters.

Only applications received no later than 20 June can be considered.

Interviews will take place on 3 and 5 July.               

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