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Postdoctoral researcher, Theoretical modelling of light-activated metal-based metabolic enzyme inhibitors

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30 april 2019
01 juni 2019

Nog 6 dagen om te solliciteren

The Faculty of Science and the Leiden Institute of Chemistry are looking for a

Postdoctoral researcher, Theoretical modelling of light-activated metal-based metabolic enzyme inhibitors

Project description
This postdoctoral position is part of the NWO-funded VICI project ‘Ru2TARGET: Synergistic light-activated metal-based metabolic enzyme inhibitors’. The aim of this project is about developing photoactivated chemotherapy, a new form of anticancer treatment based on light-activated pharmacological compounds.

The postdoc position will be hosted within the group of Dr. Sylvestre Bonnet, whose research focus is on performing photochemistry in biological and biomimetic environments. Embedded within a multidisciplinary project, the postdoctoral collaborator will work within the coordination chemistry and catalysis group (MCBIM), which houses excellent facilities for synthesis, photochemistry, and photobiology, and will host several PhD students and postdocs with expertise in the field of light-activated metallodrugs.

Computing time will be available via a local cluster and SURFSARA, the Dutch high-performance computing facility. Strong interactions between the theoretical postdoc and the members of the experimental team are expected, aiming at designing, altogether, highly selective and effective light-activated metal-based metabolic enzyme inhibitors. The MCBIM group is internationally recognized for its work in biomimetic and biological inorganic chemistry. The postdoctoral project will be realized in close collaboration with the team of Dr. Franco Buda, a theoretical chemist from the Biophysical Organic Chemistry/Solid State NMR group, also part of the LIC. Dr. Buda is a theoretical chemist specialized in QM/MM approaches and the modelling of photochemical processes.

The candidate will have experience in the theoretical modelling of drugs and drug-proteins interactions and is interested in developing new modelling tools and approaches for metal-containing drugs.

Selection criteria

  • A PhD degree in medicinal computational chemistry or a related field;
  • Good knowledge of state-of-the-art methods for the modeling drug-protein interactions;
  • Excellent proficiency in English (as proven by IELTS: 6.5 or TOEFL: internet based 90, or equivalent);
  • A convincing publication record;
  • Proven ability to work in team, to communicate with experimental chemists, and be interested in developing new tools for theoretical modeling;
  • Previous experience in modelling photoreactive and/or inorganic compounds is a plus.

Research at our Faculty and Institute
The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science and to make a contribution to addressing the major societal challenges of the future.

The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organized in eight institutes. These institutes offer eight bachelor’s and twelve master’s programs. The faculty has grown strongly in recent years and now has more than 1,300 staff and almost 4,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together.

The chemistry and life science research in the Leiden Institute of Chemistry (LIC) https://www.universiteitleiden.nl/en/science/chemistry is organized around two major research areas: ‘Chemical Biology’ and ‘Energy & Sustainability’. The institute’s research themes illustrate the central position of chemistry between biology, medicine and physics. The various research topics carried out within these themes are ideal for executing interdisciplinary research.

Terms and conditions
We offer a full-time position for initially one year, with possible extension for another year after positive evaluation of the progress of the research. Salary range from €2.709,- to €4.274,- gross per month (pay scale 10 in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3%), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside The Netherlands may be eligible for a substantial tax break.

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Enquiries can be made to Dr. Sylvestre Bonnet bonnet@chem.leidenuniv.nl. If you have any questions about the procedure, please contact the secretary of the  Mrs. Yvonne Snellenberg snellenbergy@chem.leidenuniv.nl, telephone: +31 (0)71 527 4450.

To apply for this vacancy, please send no later than June 1, 2019 an email to the secretary of the ‘Metals in Catalysis, Biomimetics & Inorganic Materials’ group Mrs. Yvonne Snellenberg snellenbergy@chem.leidenuniv.nl.

Please ensure that you join to your application the vacancy number and the following documents:

  • A letter of motivation;
  • An updated CV of at most 3 pages, including a well-defined publication list;
  • Two written letters of recommendation, including at least one by a former PhD supervisor;
  • A digital copy of your PhD degree.

The planned starting date is July 1/August 1, 2019 (or earlier).

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