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PhD candidate for development of novel immunometabolic platforms for cancer diagnostics and pharmacotherapy

Omvang (fte)
Geplaatst op
04 april 2019
29 april 2019

Nog 7 dagen om te solliciteren

The Division of Systems Biomedicine and Pharmacology at the Leiden Academic Centre for Drug Research (LACDR) is looking for a

PhD candidate for Development of novel immunometabolic platforms for cancer diagnostics and pharmacotherapy   (1.0 FTE)

Project description
We will develop in vitro technologies to probe tumor immunometabolism at the single cell resolution. The technology will allow us to characterize tumor associated macrophage heterogeneity, study the role of the microenvironment on their function, and to monitor their behavior upon administration of inhibitors of metabolism. This could lead to a breakthrough in cancer immunotherapy and diagnostics.

Key responsibilities
The aim of your PhD project is to develop an advanced analytical and in-vitro platform for metabolic phenotyping of tumor associated macrophages. You will establish miniaturized metabolomic setups to profile metabolites for immuno metabolic characterization of 100’s of cells in cancer relevant microenvironments down to individual cells. You will optimize sample preparation in such a way that the extract after sample preparation is ideally suited for CE-MS and nano/micro LC-MS analysis. You will develop a robotic sample preparation platform and optimize nano LC-MS protocols. You will optimize sampling from an innovative cancer-on-a-chip platform, which you will help to further develop.  You will work with industrial partners (Agios, Mimetas, Sciex, SampleQ) to learn about relevant modules for this project and to test novel mass spectrometry systems and prototypes, and novel organ-on-a-chip models.

Selection criteria

  • Master/Engineering degree in Chemistry, Biochemistry, Biology or Biomedical Engineering preferably with majors in Analytical Chemistry.
  • Strong interest in technology, microfluidic, analytical chemistry; mass spectrometry; in the field of metabolomics, pharmacology, microfluidics and chemometrics applied to biological samples is desired.
  • Experience with in-vitro or organ-on-a-chip models is a pre.
  • Proficient in spoken and written English.
  • An independent and creative team player with good communicative skills.
  • Able to work independently in a multidisciplinary environment.

Our organization
The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future.
The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organized in eight institutes. These institutes offer eight bachelor’s and twelve master’s programs. The faculty has grown strongly in recent years and now has more than 1,300 staff and almost 4,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together

The Leiden Academic Centre for Drug Research (LACDR) is a leading institute dedicated to world-class research and education in drug discovery and development. LACDR comprises a diverse and international team of approximately 150 researchers and is ideally located at the Leiden Bio Science Park, the largest life science cluster in The Netherlands.

Within the LACDR there is a growing focus on using (translational) metabolomics and patient derived organ-on-a-chip systems in the areas of drug research, translational disease research, systems pharmacology, computational modeling and biostatistics, and integration with epidemiological studies, genetics and clinical studies. You will work closely with the Leiden Centre for Data Science.

The Analytical Biosciences and Metabolomics group at the LACDR has a world-leading reputation in the field of metabolomics, and has a track record in developing novel analytical and microfluidic methods.

Terms and conditions
We offer a position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary range from €2,325 to €2,972 gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities). Mobility and family allowances as applicable according to Marie Skłodowska-Curie PhD fellowship scheme for early career researchers.

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. For international spouses we have set up a dual career program. Candidates from outside the Netherlands may be eligible for a substantial tax break. More at https://www.universiteitleiden.nl/en/working-at/job-application-procedure-and-employment-conditions.

All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school. The PhD candidate will benefit from a personal career development plan with targeted training measures and participation in a range of network activities with other Logic Lab consortium partners.

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

For more information on this position, please contact Prof. Thomas Hankemeier, e-mail: hankemeier@lacdr.leidenuniv.nl. If you have any questions about the procedure, please contact Mrs. Cathy Robbers (e-mail: c.c.w.robbers@lacdr.leidenuniv.nl , telephone: +31 71 527 4220).

Information about the faculty of science can be found at http://www.science.leidenuniv.nl/index.php/english/ and about Leiden University at http://www.vacancies.leiden.edu/.

To apply for this vacancy, please send your application no later than 29th April 2019 by e-mail to: abs@lacdr.leidenuniv.nl. Please ensure that you quote the vacancy number (19-153) in the subject header and include the following additional documents quoting the vacancy number: Application letter and CV.


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