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PhD candidate: Functionalization of living endothelial cells with TTA-UC logic gates and photo-NORMs

Omvang (fte)
1.0 FTE
Intern, Extern
Geplaatst op
15 februari 2019
30 april 2019

Nog 38 dagen om te solliciteren

The Faculty of Science and the Leiden Institute of Chemistry are looking for a PhD candidate: Functionalization of living endothelial cells with TTA-UC logic gates and photo-NORMs (1.0 FTE).

Project description

This PhD position is part of the EU-funded Marie Skłodowska-Curie Innovative Training Network (ITN) ‘Molecular logic lab-on-a-vesicle for intracellular diagnostics - Logic Lab’ www.logiclab-itn.eu.

The PhD candidate will study the influence of hydrophobic substituents on the membrane/water partition coefficient, bi-dimensional diffusion coefficient, and cellular toxicity, of photoactive NO-releasing molecules and upconverting molecular logic gated sensors. The project involves synthesis and physical chemistry; its overall objective is to obtain molecular sensors and photoNORMs that can be integrated in liposomes formulation that can be used to functionalize living endothelial cells with the sensing or NO-release function.

Scientific training in partner institutions include lifetime microscopy and dye diffusion studies at Dublin City University (3 months), upconversion NO release studies at the Friedrich Schiller University Jena (2 months) and working at company Mimetas on an artery model (1 month).

Selection criteria

  • Master’s degree in Chemistry or a related field;
  • Good knowledge and interest in both synthetic and physical chemistry;
  • Proven competence in synthesis, spectroscopy, chemical biology or bioinorganic chemistry;
  • Knowledge of (bio)chemical sensing and/or membrane (bio)chemistry is a plus;
  • Good to excellent proficiency in English is required (as proven by IELTS: 6.5 or TOEFL: internet based 90, or equivalent);
  • Ability to work independently in a multidisciplinary environment;
  • Meeting the Marie Skłodowska-Curie Early Stage Researcher eligibility criteria is required. In particular, at the time of appointment candidates must have had less than four years full-time equivalent research experience and must not have already obtained a PhD. Additionally, they must not have resided in The Netherlands for more than 12 months in the three years immediately before the appointment;
  • Planned start date July 2019 (or earlier).

Our organisation

The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future.
The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organized in eight institutes. These institutes offer eight bachelor’s and twelve master’s programs. The faculty has grown strongly in recent years and now has more than 1,300 staff and almost 4,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together.

The chemistry and life science research in the Leiden Institute of Chemistry (LIC) is organised around two major research areas: ‘Chemical Biology’ and ‘Energy & Sustainability’. The institute’s research themes illustrate the central position of chemistry between biology, medicine and physics. The various research topics carried out within these themes are ideal for executing interdisciplinary research.

Terms and conditions

We offer a position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary range from €2,325 to €2,972 gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities). Mobility and family allowances as applicable according to Marie Skłodowska-Curie PhD fellowship scheme for early career researchers.

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. For international spouses we have set up a dual career programme. Candidates from outside the Netherlands may be eligible for a substantial tax break. More at https://www.universiteitleiden.nl/en/working-at/job-application-procedure-and-employment-conditions.

All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school. The PhD candidate will benefit from a personal career development plan with targeted training measures and participation in a range of network activities with other Logic Lab consortium partners.


Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.


Enquiries can be made to Dr Sylvestre Bonnet, email bonnet@chem.leidenuniv.nl.
If you have any questions about the procedure, please contact secretary Yvonne Snellenberg, email snellenbergy@chem.leidenuniv.nl telephone +31 71 527 4450.


To apply for this vacancy, please send no later than 30 April 2019 an email to the secretary of the ‘Metals in Catalysis, Biomimetics & Inorganic Materials’ group www.universiteitleiden.nl/en/science/chemistry/mcbim, Yvonne Snellenberg at snellenbergy@chem.leidenuniv.nl.
Please ensure that you join to your application the vacancy number and the following additional documents:

  • A letter of motivation;
  • An updated CV of at most 3 pages, including a well-defined publication list;
  • Copy of master’s thesis or any other publications (if available);
  • The transcripts of your MSc studies and copy of your degree;
  • Two written letters of recommendation by former supervisors.


Enquiries from agencies are not appreciated.

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