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Daan van Valkengoed

‘My name is Daan van Valkengoed, and I am a master student Bio-Pharmaceutical Sciences. Last year I conducted my bachelor research internship within the research group Predictive Pharmacology of the LACDR. During my research, I used a mathematical model developed by the Predictive Pharmacology group to simulate the distribution of two anti-cancer agents through the brain. With this model the effect of brain tumours on this distribution could be simulated. '

I hope the results of my research stimulate researchers to focus more on determining quantitative changes in active transporter expression

Simulating drug distribution into tumours

'An important player in brain distribution of drugs is the 'blood-brain barrier' (BBB), which effectively shields the brain from drugs. Physiological changes caused by brain tumours could be determined and implemented in the model. By doing so I was able to simulate drug distribution into brain tumours. This showed how the distribution is different compared to healthy brain.

Daan van Valkengoed

Improving brain tumour treatment

My results highlight the importance of active efflux transporters at the BBB (protein 'pumps' that move drugs from the brain back to the blood) in determining drug distribution to brain tumours. The results suggest that heterogeneous transporter expression might be an important reason why the treatment of brain tumours often fails. My hope is that the results stimulate researchers to focus more on determining quantitative changes in active transporter expression, as this knowledge might ultimately help in improving brain tumour treatment.’

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