Bas Goulooze is our Leiden Academic Centre for Drug Research's nominee for the C.J. Kok Jury Award 2020.
About Bas' research
Pharmacometrician Bas Goulooze obtained his PhD on models describing the pharmacodynamics (effects over time) of pain medication such as morphine and fentanyl. In the case of painkillers or analgesics, there is a lack of pharmacodynamic knowledge, as a result of which some patients initially receive too much or too little morphine before the correct dose has been found. To use the scarce clinical data in this area, Goulooze has developed innovative model-based solutions, taking new steps in describing and predicting pain relief.
‘With the new tools that we developed, we advanced the field of pharmacodynamics research and helped address long-standing clinical questions on the optimal treatment of pain.’
He has also developed two models for withdrawal symptoms in children after long-term use of pain medication. These models can be used to quantify the occurrence of drug withdrawal syndrome and provided new insights that may reduce its occurrence in critically ill children in the future. With this dissertation, Goulooze gave a new impulse to research into the pharmacodynamics of pain and withdrawal, a subject on which little progress had been made. His scientific work was awarded the prestigious Lewis Sheiner Student Session Prize towards the end of his PhD trajectory in 2019, and he obtained his PhD cum laude.