Roeland Dirks
- Naam
- Dr. R.W. Dirks
- Telefoon
- +31 71 526 9111
- r.w.dirks@lumc.nl
- Faculteit Geneeskunde
- Divisie 4
- Cel en Chemische biologie
- Dekker, P.; Meissner, A.; Dirks, R.W.; Slagboom, P.E.; Heemst, D. van; Deelder, A.M.; Tanke, H.J.; Westendorp, R.G.J. & Maier, A.B. (2012), Human in vivo longevity is reflected in vitro by differential metabolism as measured by H-1-NMR profiling of cell culture supernatants.
- van der Laan Annelies M. A., van Gemert Alice M. C., Dirks Roeland W., Noordermeer Jasprina N., Fradkin Lee G., Tanke Hans J. & Jost Carolina R. (2012), mRNA cycles through hypoxia-induced stress granules in live Drosophila embryonic muscles, International Journal of Developmental Biology 56(9): 701-709.
- Laan, A.M.A. van der; Gemert, A.M.C. van; Dirks, R.W.; Noordermeer, J.N.; Fradkin, L.G.; Tanke, H.J. & Jost, C.R. (2012), mRNA cycles through hypoxia-induced stress granules in live Drosophila embryonic muscles., International Journal of Developmental Biology 56(9): 701-9.
- Dekker, P.; Gunn, D.; McBryan, T.; Dirks, R.W.; Heemst, D. van; Lim, F.L.; Jochemsen, A.G.; Verlaan-de Vries, M.; Nagel, J.; Adams, P.D.; Tanke, H.J.; Westendorp, R.G.J. & Maier, A.B. (2012), Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts, Mechanisms of Ageing and Development 133(7): 498-507.
- Dekker, P.; Baalen, L.M. van; Dirks, R.W.; Slagboom, P.E.; Heemst, D. van; Tanke, H.J.; Westendorp, R.G.J. & Maier, A.B. (2012), Chronic Inhibition of the Respiratory Chain in Human Fibroblast Cultures: Differential Responses Related to Subject Chronological and Biological Age, Journals of Gerontology, Series A 67(5): 456-464.
- Wiegant J, Brouwer AK, Tanke HJ & Dirks RW (2010), Visualizing nucleic acids in living cells by fluorescence in vivo hybridization., Methods in Molecular Biology 659: 239-46.
- Dekker, P.; Lange, M.J. de; Dirks, R.W.; Heemst, D. van; Tanke, H.J.; Westendorp, R.G.J. & Maier, A.B. (2011), Relation Between Maximum Replicative Capacity and Oxidative Stress-Induced Responses in Human Skin Fibroblasts In Vitro., Journals of Gerontology, Series A.
- Jonsdottir, A.B.; Dirks, R.W.; Vrolijk, J.; Ogmundsdottir, H.M.; Tanke, H.J.; Eyfjord, J.E. & Szuhai, K. (2010), Centriole movements in mammalian epithelial cells during cytokinesis, BMC Cell Biology 11.
- Mair, G.R.; Lasonder, E.; Garver, L.S.; Franke-Fayard, B.M.D.; Carret, C.K.; Wiegant, J.C.A.G.; Dirks, R.W.; Dimopoulos, G.; Janse, C.J. & Waters, A.P. (2010), Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development., PLoS Pathogens 6(2): e1000767.
- Mair, G.R.; Lasonder, E.; Garver, L.S.; Franke-Fayard, B.M.D.; Carret, C.K.; Wiegant, J.C.A.G.; Dirks, R.W.; Dimopoulos, G.; Janse, C.J. & Waters, A.P. (2010), Universal Features of Post-Transcriptional Gene Regulation Are Critical for Plasmodium Zygote Development, PLoS Pathogens 6(2).
- van Gemert AMC, Jost CR, van der Laan AMA, Dirks RW, Reiber JHC, Tanke HJ & Lelieveldt BPF (2009), IDENTIFICATION OF CELLULAR DYNAMIC PATTERNS RESULTING FROM REPETITIVE PHOTOBLEACHING USING INDEPENDENT COMPONENT ANALYSIS, 2009 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO, VOLS 1 AND 2: 1382-1385.
- Noppe G, Dekker P, de Koning-Treurniet C, Blom J, van Heemst D, Dirks RW, Tanke HJ, Westendorp RGJ & Maier AB (2009), Rapid Flow Cytometric Method for Measuring Senescence Associated beta-Galactosidase Activity in Human Fibroblasts, Cytometry Part A 75A(11): 910-916.
- Brouwer, A.K.; Schimmel, J.; Wiegant, J.C.A.G.; Vertegaal, A.C.O.; Tanke, H.J. & Dirks, R.W. (2009), Telomeric DNA mediates de novo PML body formation., Molecular Biology of the Cell 20(22): 4804-15.
- Brouwer AK, Schimmel J, Wiegant JCAG, Vertegaal ACO, Tanke HJ & Dirks RW (2009), Telomeric DNA Mediates De Novo PML Body Formation, Molecular Biology of the Cell 20(22): 4804-4815.
- Dekker P, Maier AB, van Heemst D, de Koning-Treurniet C, Blom J, Dirks RW, Tanke HJ & Westendorp RGJ (2009), Stress-induced responses of human skin fibroblasts in vitro reflect human longevity, Aging Cell 8(5): 595-603.
- Raz V, Vermolen BJ, Garini Y, Onderwater JJM, Mommaas-Kienhuis MA, Koster AJ, Young IT, Tanke H & Dirks RW (2008), The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells, Journal of Cell Science 121(24).
- Vermolen BJ, Garini Y, Young IT, Dirks RW & Raz V (2008), Segmentation and analysis of the three-dimensional redistribution of nuclear components in human mesenchymal stem cells, Cytometry Part A 73A(9).
- Wiesmeijer K, Krouwels IM, Tanke HJ & Dirks RW (2008), Chromatin movement visualized with photoactivable GFP-labeled histone H4, Differentiation 76(1).
- Shir OM, Raz V, Dirks RW & Back T (2007), Classification of cell fates with Support Vector Machine learning, Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics, Proceedings 4447: 258-269.
- Raz V, Carlotti F, Vermolen BJ, van der Poel E, Sloos WCR, Knaan-Shanzer S, de Vries AAF, Hoeben RC, Young IT, Tanke HJ, Garini Y & Dirks RW (2006), Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells, Journal of Cell Science 119(20).
- Mair GR, Braks JAM, Garver LS, Wiegant LCAG, Hall N, Dirks RW, Khan SM, Dimopoulos G, Janse CJ & Waters AP (2006), Regulation of sexual development of Plasmodium by translational repression, Science 313(5787).
- Dirks RW & Tanke HJ (2006), Styryl molecules light-up RNAs, Cell Chemistry Biology 13(6): 559-560.
- Dirks RW & Tanke HJ (2006), Advances in fluorescent tracking of nucleic acids in living cells, BioTechniques 40(4).
- Krouwels IM, Wiesmeijer K, Abraham TE, Molenaar C, Verwoerd NP, Tanke HJ & Dirks RW (2005), A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain, Journal of Cell Biology 170(4).
- Meulmeester E, Maurice MM, Boutell C, Teunisse AFAS, Ovaa H, Abraham TE, Dirks RW & Jochemsen AG (2005), Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2, Molecular Cell 18(5).
- Tanke HJ, Dirks RW & Raap T (2005), FISH and immunocytochemistry: towards visualising single target molecules in living cells, Current Opinion in Biotechnology 16(1).
- Rieger B, Molenaar C, Dirks RW & Van Vliet LJ (2004), Alignment of the cell nucleus from labeled proteins only for 4D in vivo imaging, Microscopy Research and Technique 64(2).
- Molenaar C, Abdulle A, Gena A, Tanke HJ & Dirks RW (2004), Poly(A)(+) RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells, Journal of Cell Biology 165(2).
- van Koningsbruggen S, Dirks RW, Mommaas AM, Onderwater JJ, Deidda G, Padberg GW, Frants RR & van der Maarel SM (2004), FRG1P is localised in the nucleolus, Cajal bodies, and speckles, Journal of Medical Genetics 41(4).
- Molenaar C, Wiesmeijer K, Verwoerd NP, Khazen S, Eils R, Tanke HJ & Dirks RW (2003), Visualizing telomere dynamics in living mammalian cells using PNA probes, EMBO Journal 22(24).
- van Koningsbruggen S, de Haard H, de Kievit P, Dirks RW, van Remoortere A, Groot AJ, van Engelen BGM, den Dunnen JT, Verrips CT, Frants RR & van der Maarel SM (2003), Llama-derived phage display antibodies in the dissection of the human disease oculopharyngeal muscular dystrophy, Journal of Immunological Methods 279(1-2).
- Dirks RW, Molenaar C & Tanke HJ (2003), Visualizing RNA molecules inside the nucleus of living cells, Methods 29(1).
- Wiesmeijer K, Molenaar C, Bekeer IMLA, Tanke HJ & Dirks RW (2002), Mobile foci of Sp100 do not contain PML: PML bodies are immobile but PML and Sp100 proteins are not, Journal of Structural Biology 140(1-3).
- Hattinger CM, Jochemsen AG, Tanke HJ & Dirks RW (2002), Induction of p21 mRNA synthesis after short-wavelength UV light visualized in individual cells by RNA FISH, Journal of Histochemistry and Cytochemistry 50(1).
- Snaar SP, Verdijk P, Tanke HJ & Dirks RW (2002), Kinetics of HCMV immediate early mRNA expression in stably transfected fibroblasts, Journal of Cell Science 115(2).
- Szuhai K, Sandhaus E, Kolkman-Uljee SM, Lemaitre M, Truffert JC, Dirks RW, Tanke HJ, Fleuren GJ, Schuuring E & Raap AK (2001), A novel strategy for human papillomavirus detection and genotyping with SybrGreen and molecular beacon polymerase chain reaction, American Journal of Pathology 159(5).
- Szuhai K, van den Ouweland JM, Dirks RW, Lemaitre M, Truffert JC, Janssen GM, Tanke HJ, Holme E, Maassen JA & Raap AK (2001), Simultaneous A8344G heteroplasmy and mitochondrial DNA copy number quantification in Myoclonus Epilepsy and Ragged-Red Fibers (MERRF) Syndrome by a multiplex Molecular Beacon based real-time fluorescence PCR, Nucleic Acids Research 29(3): -.
- Dirks RW, Molenaar C & Tanke HJ (2001), Methods for visualizing RNA processing and transport pathways in living cells, Histochemistry and Cell Biology 115(1).
- van Koningsbruggen S, Deidda G, Dirks RW, Mommaas AM, Onderwater J, Padberg GW, Frants RR & van der Maarel SM (2000), The localization of FRG1P in the nucleolus, Cajal bodies and speckles implies a fundamental role in RNA processing., American Journal of Human Genetics 67(4): 181-181.
- Snaar S, Wiesmeijer K, Jochemsen AG, Tanke HJ & Dirks RW (2000), Mutational analysis of fibrillarin and its mobility in living human cells, Journal of Cell Biology 151(3).
- Szuhai K, Bezrookove V, Wiegant J, Vrolijk J, Dirks RW, Rosenberg C, Raap AK & Tanke HJ (2000), Simultaneous molecular karyotyping and mapping of viral DNA integration sites by 25-color COBRA-FISH.
- van den Ouweland JMW, de Klerk JBC, van de Corput MP, Dirks RW, Raap AK, Scholte HR, Huijmans JGM, Hart LMT, Bruining GJ & Maassen JA (2000), Characterization of a novel mitochondrial DNA deletion in a patient with a variant of the Pearson marrow-pancreas syndrome.
- Dirks RW, Hattinger CM, Molenaar C & Snaar SP (1999), Synthesis, processing, and transport of RNA within the three-dimensional context of the cell nucleus.