Lucas Teppema
- Naam
- Dr. L.J.S.M. Teppema
- Telefoon
- +31 71 526 3607
- l.j.s.m.teppema@lumc.nl
- Faculteit Geneeskunde
- LUMC - Medische Faculteit Leiden
- Divisie 1
- Anesthesiologie
- Teppema, L.J.; Boulet, L.M.; Hackett, H.K.; Dominelli, P.B.; Cheyne, W.S.; Dominelli, G.S.; Swenson, E.R. & Foster, G.E. (2019), Influence of methazolamide on the human control of breathing: A comparison to acetazolamide, Experimental Physiology.
- Boulet, L.M.; Teppema, L.J.; Hackett, H.K.; Dominelli, P.B.; Cheyne, W.S.; Dominelli, G.S.; Irwin, D.C.; Buehler, P.W.; Baek, J.H.; Swenson, E.R. & Foster, G.E. (2018), Attenuation of human hypoxic pulmonary vasoconstriction by acetazolamide and methazolamide, Journal of Applied Physiology 125(6): 1795-1803.
- Dominelli, P.B.; McNeil, C.J.; Vermeulen, T.D.; Stuckless, T.J.R.; Brown, C.V.; Dominelli, G.S.; Swenson, E.R.; Teppema, L.J. & Foster, G.E. (2018), Effect of acetazolamide and methazolamide on diaphragm and dorsiflexor fatigue: a randomized controlled trial, Journal of Applied Physiology 125(3): 770-779.
- Berendsen, R.R.; Vessem, M.E. van; Bruins, M.; Teppema, L.J.S.M.; Aarts, L.P.H.J. & Kayser, B. (2018), Electronic Nose Technology Fails to Sniff Out Acute Mountain Sickness, High Altitude Medicine and Biology 19(3): 232-236.
- Baby, S.M.; Gruber, R.B.; Young, A.P.; MacFarlane, P.M.; Teppema, L.J. & Lewis, S.J. (2018), Bilateral carotid sinus nerve transection exacerbates morphine-induced respiratory depression, European Journal of Pharmacology 834: 17-29.
- Teppema, L.J. (2018), CrossTalk opposing view: the hypoxic ventilatory response does not include a central, excitatory hypoxia sensing component, Journal of Physiology 596(15): 2939-2941.
- Berendsen, R.R.; Lindeman, R.C.; Boom, M.; Aarts, L.P.H.J.; Dorp, E.L.A. van & Teppema, L.J. (2016), Erythropoietin does not have effects on the ventilatory and pulmonary vascular response to acute hypoxia in men and women, Experimental Physiology 101(9): 1230-1240.
- Wilson, R.J.A. & Teppema, L.J. (2016), Integration of Central and Peripheral Respiratory Chemoreflexes, Comprehensive Physiology 6(2): 1005-1041.
- Teppema, L.J. & Berendsen, R.R. (2016), Relationship between blood pressure and cerebral blood flow during supine cycling: influence of aging, Journal of Applied Physiology 120(5): 564-564.
- Teppema, L.J. & Smith, C.A. (2013), CrossTalk opposing view: Peripheral and central chemoreceptors have hyperadditive effects on respiratory motor control, Journal of Physiology 591(18): 4359-4361.
- Teppema, L.J. & Smith, C.A. (2013), Rebuttal from Luc J. Teppema and Curtis A. Smith, Journal of Physiology 591(18): 4367-4367.
- Teppema, L.J. & Berendsen, R.R. (2012), Response to the reply of J. Duffin to our letter entitled 'Acetazolamide and cerebrovascular function at high altitude', JOURNAL OF PHYSIOLOGY-LONDON 590(15): 3625-3626.
- Teppema, L.J. & Berendsen, R.R. (2012), Acetazolamide and cerebrovascular function at high altitude, JOURNAL OF PHYSIOLOGY-LONDON 590(12): 2945-2946.
- Olofsen, E.; Boom, M.; Nieuwenhuijs, D.; Sarton, E.; Teppema, L.; Aarts, L. & Dahan, A. (2010), Modeling the Non-Steady State Respiratory Effects of Remifentanil in Awake and Propofol-sedated Healthy Volunteers, Anesthesiology 112(6): 1382-1395.
- Olofsen, E.; Dorp, E. van; Teppema, L.; Aarts, L.; Smith, T.W.; Dahan, A. & Sarton, E. (2010), Naloxone Reversal of Morphine- and Morphine-6-Glucuronide-induced Respiratory Depression in Healthy Volunteers A Mechanism-based Pharmacokinetic-Pharmacodynamic Modeling Study, Anesthesiology 112(6): 1417-1427.
- Teppema, L.J. & Dahan, A. (2010), The Ventilatory Response to Hypoxia in Mammals: Mechanisms, Measurement, and Analysis, Physiological Reviews 90(2): 675-754.
- Teppema, L.J.; Dorp, E.L.A. van & Dahan, A. (2010), Arterial [H+] and the ventilatory response to hypoxia in humans: influence of acetazolamide-induced metabolic acidosis, AJP - Lung Cellular and Molecular Physiology 298(1): L89L95.
- Bayley, J.P.; Minderhout, I. van; Hogendoorn, P.C.W.; Cornelisse, C.J.; Wal, A. van der; Prins, F.A.; Teppema, L.; Dahan, A.; Devilee, P. & Taschner, P.E.M. (2009), Sdhd and Sdhd/H19 Knockout Mice Do Not Develop Paraganglioma or Pheochromocytoma, PLoS ONE 4(11).
- Kiwull-Schone HF, Li Y, Kiwull PJ & Teppema LJ (2009), Methazolamide does not impair respiratory work performance in anesthetized rabbits, AJP - Regulatory, Integrative and Comparative Physiology 297(3): R648R654.
- Kiwull-Schone H, Teppema L, Wiemann M, Kalhoff H & Kiwull P (2008), Pharmacological impact on loop gain properties to prevent irregular breathing, Journal of Physiology and Pharmacology 59(1).
- Sarton E, Teppema L & Dahan A (2008), Naloxone reversal of opioid-induced respiratory depression with special emphasis on the partial agonist/antagonist buprenorphine, Advances in Experimental Medicine and Biology 605.
- Dahan A, Sarton E & Teppema L (2008), Plasticity in the brain: Influence of bilateral carotid body resection (bCBR) on central CO2 sensitivity, Advances in Experimental Medicine and Biology 605.
- van Dorp E, Los M, Dirven P, Sarton E, Valk P, Teppema L, Stienstra R & Dahan A (2007), Inspired carbon dioxide during hypoxia: Effects on task performance and cerebral oxygen saturation, Aviation, Space, and Environmental Medicine 78(7).
- Dahan A, Nieuwenhuijs D & Teppema L (2007), Plasticity of central chemoreceptors: Effect of bilateral carotid body resection on central CO2 sensitivity.
- Teppema LJ, Balanos GM, Steinback CD, Brown AD, Foster GE, Duff HJ, Leigh R & Poulin MJ (2007), Effects of acetazolamide on ventilatory, cerebrovascular, and pulmonary vascular responses to hypoxia, American Journal of Respiratory and Critical Care Medicine 175(3).
- Yassen A, Ofsen E, Romberg R, Sarton E, Teppema L, Danhof M & Dahan A (2007), Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers, Clinical Pharmacology and Therapeutics 81(1).
- Yassen A, Olofsen E, van Dorp E, Sarton E, Teppema L, Danhof M & Dahan A (2007), Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone - A study in healthy volunteers, Clinical Pharmacokinetics 46(11).
- van Dorp E, Yassen A, Sarton E, Romberg R, Olofsen E, Teppema L, Danhof M & Dahan A (2006), Naloxone reversal of buprenorphine-induced respiratory depression, Anesthesiology 105(1).
- Teppema LJ, Bijl H, Gourabi BM & Dahan A (2006), The carbonic anhydrase inhibitors methazolamide and acetazolamide have different effects on the hypoxic ventilatory response in the anaesthetized cat, Journal of Physiology 574(2).
- Dahan A, Yassen A, Romberg R, Sarton E, Teppema L, Olofsen E & Danhof M (2006), Buprenorphine induces ceiling in respiratory depression but not in analgesia, British Journal of Anaesthesia 96(5).
- Teppema LJ, Bijl H, Romberg RR & Dahan A (2006), Antioxidants reverse depression of the hypoxic ventilatory response by acetazolamide in man, Journal of Physiology 572(3).
- Bijl JHL, Gourabi BM, Dahan A & Teppema LJ (2006), Effects of low-dose methazolamide on the control of breathing in cats, Advances in Experimental Medicine and Biology 580.
- Kiwull-Schone H, Teppema L, Wiemann M & Kiwull P (2006), Loop gain of respiratory control upon reduced activity of carbonic anhydrase or Na+/H+ exchange, Advances in Experimental Medicine and Biology 580.
- Dahan A, Yassen A, Bijl H, Romberg R, Sarton E, Teppema L, Olofsen E & Danhof M (2005), Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats, British Journal of Anaesthesia 94(6).
- Teppema LJ, Romberg RR & Dahan A (2005), Antioxidants reverse reduction of the human hypoxic ventilatory response by subanesthetic isoflurane, Anesthesiology 102(4).
- Romberg RR, Olofsen E, Bijl H, Taschner PEM, Teppema LJ, Sarton EY, van Kleef JW & Dahan A (2005), Polymorphism of mu-opioid receptor gene (OPRM1 : c.118A > G) does not protect against opioid-induced respiratory depression despite reduced analgesic response, Anesthesiology 102(3).
- Romberg R, Olofsen E, Sarton E, Teppema L & Dahan A (2004), Increased margin of safety of morphine-6-glucuronide relative to morphine, Anesthesiology 100(6).
- Dahan A, Taschner PEM, Jansen JC, van der Mey A, Teppema LJ & Cornelisse CJ (2004), Carotid body tumors in humans caused by a mutation in the gene for succinate dehydrogenase D (SDHD), Advances in Experimental Medicine and Biology 551.
- Romberg R, Sarton E, Teppema L, Matthes HWD, Kieffer BL & Dahan A (2003), Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild type and mu-opioid receptor deficient mice, British Journal of Anaesthesia 91(6).
- Romberg R, Olofsen E, Sarton E, Teppema L & Dahan A (2003), Pharmacodynamic effect of morphine-6-glucuronide versus morphine on hypoxic and hypercapnic breathing in healthy volunteers, Anesthesiology 99(4).
- Dahan A & Teppema LJ (2003), Influence of anaesthesia and analgesia on the control of breathing, British Journal of Anaesthesia 91(1).
- Fatemian M, Nieuwenhuijs DJF, Teppema LJ, Meinesz S, van der Mey AGL, Dahan A & Robbins PA (2003), The respiratory response to carbon dioxide in humans with unilateral and bilateral resections of the carotid bodies, Journal of Physiology 549(3).
- Teppema LJ, Nieuwenhuijs D, Olievier CN & Dahan A (2003), Respiratory depression by tramadol in the cat - Involvement of opioid receptors, Anesthesiology 98(2).
- Nieuwenhuijs DJF, Olofsen E, Romberg RR, Sarton E, Ward D, Engbers F, Vuyk J, Mooren R, Teppema LJ & Dahan A (2003), Response surface modeling of remifentanil-propofol interaction on cardiorespiratory control and bispectral index, Anesthesiology 98(2).
- Wagenaar M, Vos PJ, Heijdra YF, Teppema LJ & Folgering HTM (2002), Combined treatment with acetazolamide and medroxyprogesterone in chronic obstructive pulmonary disease patients, European Respiratory Journal 20(5).
- Teppema LJ, Nieuwenhuijs D, Sarton E, Romberg R, Olievier CN, Ward DS & Dahan A (2002), Antioxidants prevent depression of the acute hypoxic ventilatory response by subanaesthetic halothane in men, Journal of Physiology 544(3).
- Sarton E, Romberg R, Nieuwenhuijs D, Teppema LJ, Vuyk J, Schraag S & Dahan A (2002), Influence of anaesthetic agents on perioperative control of breathing, Anaesthesist 51(4).
- Van Mil AHM, Spilt A, Van Buchem MA, Bollen ELEM, Teppema L, Westendorp RGJ & Blauw GJ (2002), Nitric oxide mediates hypoxia-induced cerebral vasodilation in humans, Journal of Applied Physiology 92(3).
- Sarton E, Teppema LJ, Olievier C, Nieuwenhuijs D, Matthes HWD, Kieffer BL & Dahan A (2001), The involvement of the mu-opioid receptor in ketamine-induced respiratory depression and antinociception, Anesthesia and Analgesia 93(6).
- Teppema LJ, Dahan A & Olievier CN (2001), Low-dose acetazolamide reduces CO2-O-2 stimulus interaction within the peripheral chemoreceptors in the anaesthetised cat, Journal of Physiology 537(1).
- Nieuwenhuijs D, Sarton E, Teppema LJ, Kruyt E, Olievier I, van Kleef J & Dahan A (2001), Respiratory sites of action of propofol - Absence of depression of peripheral chemoreflex loop by low-dose propofol, Anesthesiology 95(4).
- Dahan A, Nieuwenhuijs D, Olofsen E, Sarton E, Romberg R & Teppema L (2001), Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and bispectral index, Anesthesiology 94(6).
- Dahan A, Sarton E, Teppema L, Olievier C, Nieuwenhuijs D, Matthes HWD & Kieffer BL (2001), Anesthetic potency and influence of morphine and sevoflurane on respiration in mu-opioid receptor knockout mice, Anesthesiology 94(5).
- Kiwull-Schone HF, Teppema LJ & Kiwull PJ (2001), Low-dose acetazolamide does affect respiratory muscle function in spontaneously breathing anesthetized rabbits, American Journal of Respiratory and Critical Care Medicine 163(2).
- Sarton E, Teppema L, Nieuwenhuijs D, Matthes HWD, Kieffer B & Dahan A (2001), Opioid effect on breathing frequency and thermogenesis in mice lacking exon 2 of the mu-opioid receptor gene, Advances in Experimental Medicine and Biology 499.
- Olofsen E, Nieuwenhuijs DJF, Sarton EY, Teppema LJ & Dahan A (2001), Response surface modeling of drug interactions on cardiorespiratory control, Advances in Experimental Medicine and Biology 499.
- Sarton E, Olofsen E, Romberg R, den Hartigh J, Kest B, Nieuwenhuijs D, Burm A, Teppema L & Dahan A (2000), Sex differences in morphine analgesia - An experimental study in healthy volunteers, Anesthesiology 93(5).
- Teppema L, Sarton E, Dahan A & Olievier CN (2000), The neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI) and morphine act independently on the control of breathing.
- Wagenaar M, Teppema LJ, Berkenbosch A, Olievier CN & Folgering HTM (2000), Medroxyprogesterone acetate with acetazolamide stimulates breathing in cats.
- Nieuwenhuijs D, Sarton E, Teppema L & Dahan A (2000), Propofol for monitored anesthesia care - Implications on hypoxic control of cardiorespiratory responses.