Johannes van Dam
- Naam
- Dr.ir. J.A.F. van Dam
- Telefoon
- +31 71 526 9111
- j.a.f.van_dam@lumc.nl
- Faculteit Geneeskunde
- Divisie 4
- Cel en Chemische biologie
- Xie, F.; Zhou, X.X.; Su, P.; Li, H.Y.; Tu, Y.F.; , J.J. du; Pan, C.; Wei, X.; Zheng, M.; Jin, K.; Miao, L.Y.; Wang, C.; Meng, X.L.; Dam, H. van; Dijke, P. ten; Zhang, L. & Zhou, F.F. (2022), Breast cancer cell-derived extracellular vesicles promote CD8(+) T cell exhaustion via TGF-beta type II receptor signaling, Nature Communications 13(1).
- Sundqvist, A.; Vasilaki, E.; Voytyuk, O.; Bai, Y.; Morikawa, M.; Moustakas, A.; Miyazono, K.; Heldin, C.H.; Dijke, P. ten & Dam, H. van (2020), TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness, Oncogene 39(22): 4436-4449.
- Li, Y.H.; Cui, C.; Xie, F.; Kielbasa, S.; Mei, H.L.; Dinther, M. van; Dam, H. van; Bauer, A.; Zhang, L. & Dijke, P. ten (2020), VprBP mitigates TGF-beta and Activin signaling by promoting Smurf1-mediated type I receptor degradation, Journal of Molecular Cell Biology 12(2): 138-151.
- Sundqvist, A.; Voytyuk, O.; Hamdi, M.; Popeijus, H.E.; Bijlsma-van der Burgt, C.; Janssen, J.; Martens, J.W.M.; Moustakas, A.; Heldin, C.H.; Dijke, P. ten & Dam, H. van (2019), JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses, Cells 8(12).
- Ren, J.; Smid, M.; Iaria, J.; Salvatori, D.C.F.; Dam, H. van; Zhu, H.J.; Martens, J.W.M. & Dijke, P. ten (2019), Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression, Breast Cancer Research 21(1).
- Sanchez-Duffhues, G.; Vinuesa, A.G. de; Pol, V. van de; Geerts, M.E.; Vries, M.R. de; Janson, S.G.T.; Dam, H. van; Lindeman, J.H.; Goumans, M.J. & Dijke, P. ten (2019), Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2, Journal of Pathology 247(3): 333-346.
- Zhang, Z.K.; , J.J. du; Wang, S.; Shao, L.; Jin, K.; Li, F.; Wei, B.J.; Ding, W.; Fu, P.F.; Dam, H. van; Wang, A.J.; Jin, J.; Ding, C.; Yang, B.; Zheng, M.; Feng, X.H.; Guan, K.L. & Zhang, L. (2019), OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ, Molecular Cell 73(1): 7-+.
- Dai, T.; Wu, L.M.; Wang, S.; Wang, J.; Xie, F.; Zhang, Z.K.; Fang, X.W.; Li, J.X.; Fang, P.F.; Li, F.; Jin, K.; Dai, J.F.; Yang, B.; Zhou, F.F.; Dam, H. van; Cai, D.C.; Huang, H.Z. & Zhang, L. (2018), FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection, Cell Host and Microbe 24(6): 776-+.
- Staalduinen, J. van; Baker, D.; Dijke, P. ten & Dam, H. van (2018), Epithelial-mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?, Oncogene 37(48): 6195-6211.
- Gao, L.; Wang, L.; Dai, T.; Jin, K.; Zhang, Z.K.; Wang, S.; Xie, F.; Fang, P.F.; Yang, B.; Huang, H.Z.; Dam, H. van; Zhou, F.F. & Zhang, L. (2018), Tumor-derived exosomes antagonize innate antiviral immunity, Nature Immunology 19(3): 233-+.
- Sundqvist, A.; Morikawa, M.; Ren, J.; Vasilaki, E.; Kawasaki, N.; Kobayashi, M.; Koinuma, D.; Aburatani, H.; Miyazono, K.; Heldin, C.H.; Dam, H. van & Dijke, P. ten (2018), JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion, Nucleic Acids Research 46(3): 1180-1195.
- Xie, F.; Ling, L.; Dam, H. van; Zhou, F.F. & Zhang, L. (2018), TGF-beta signaling in cancer metastasis, Acta Biochimica et Biophysica Sinica 50(1): 121-132.
- Zhang, Z.K.; Fan, Y.; Xie, F.; Zhou, H.; Jin, K.; Shao, L.; Shi, W.H.; Fang, P.F.; Yang, B.; Dam, H. van; Dijke, P. ten; Zheng, X.F.; Yan, X.H.; Jia, J.L.; Zheng, M.; Jin, J.; Ding, C.; Ye, S.; Zhou, F.F. & Zhang, L. (2017), Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7, Nature Communications 8.
- Wang, S.; Xie, F.; Chu, F.; Zhang, Z.K.; Yang, B.; Dai, T.; Gao, L.; Wang, L.; Ling, L.; Jia, J.L.; Dam, H. van; Jin, J.; Zhang, L. & Zhou, F.F. (2017), YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKK epsilon-mediated phosphorylation, Nature Immunology 18(7): 733-+.
- Jin, K.; Li, T.; Dam, H. van; Zhou, F.F. & Zhang, L. (2017), Molecular insights into tumour metastasis: tracing the dominant events, Journal of Pathology 241(5): 567-577.
- Xie, F.; Jin, K.; Shao, L.; Fan, Y.; Tu, Y.F.; Li, Y.H.; Yang, B.; Dam, H. van; Dijke, P. ten; Weng, H.L.; Dooley, S.; Wang, S.A.; Jia, J.L.; Jin, J.; Zhou, F.F. & Zhang, L. (2017), FAF1 phosphorylation by AKT accumulates TGF-beta type II receptor and drives breast cancer metastasis, Nature Communications 8.
- Zhou, F.F.; Li, F.; Fang, P.F.; Dai, T.; Yang, B.; Dam, H. van; Jia, J.L.; Zheng, M. & Zhang, L. (2016), Ubiquitin-Specific Protease 4 Antagonizes Osteoblast Differentiation Through Dishevelled, Journal of Bone and Mineral Research 31(10): 1888-1898.
- Liu, S.J.; Boeck, M. de; Dam, H. van & Dijke, P. ten (2016), Regulation of the TGF-beta pathway by deubiquitinases in cancer, International Journal of Biochemistry and Cell Biology 76: 135-145.
- Li, Y.H.; Jin, K.; Pelt, G.W. van; Dam, H. van; Yu, X.; Mesker, W.E.; Dijke, P. ten; Zhou, F.F. & Zhang, L. (2016), c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/beta-Catenin/Axin2 Pathway, Cancer Research 76(11): 3364-3375.
- Carthy, J.M.; Sundqvist, A.; Heldin, A.; Dam, H. van; Kletsas, D.; Heldin, C.H. & Moustakas, A. (2015), Tamoxifen Inhibits TGF-beta-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2, Journal of Cellular Physiology 230(12): 3084-3092.
- Li, Y.H.; Drabsch, Y.; Pujuguet, P.; Ren, J.; Laar, T. van; Zhang, L.; Dam, H. van; Clement-Lacroix, P. & Dijke, P. ten (2015), Genetic depletion and pharmacological targeting of alpha v integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models, Breast Cancer Research 17.
- Dijke, P. ten & Dam, H. van (2015), 14-3-3 zeta Turns TGF-beta to the Dark Side, Cancer Cell 27(2): 151-153.
- Zhang, J.; Zhang, X.F.; Xie, F.; Zhang, Z.K.; Dam, H. van; Zhang, L. & Zhou, F.F. (2014), The regulation of TGF-beta/SMAD signaling by protein deubiquitination.
- Sundqvist, A.; Zieba, A.; Vasilaki, E.; Hidalgo, C.H.; Soderberg, O.; Koinuma, D.; Miyazono, K.; Heldin, C.H.; Landegren, U.; Dijke, P. ten & Dam, H. van (2013), Specific interactions between Smad proteins and AP-1 components determine TGF beta-induced breast cancer cell invasion, Oncogene 32(31): 3606-3615.
- Zhang, X.F.; Zhang, J.; Zhang, L.; Dam, H. van & Dijke, P. ten (2013), UBE2O negatively regulates TRAF6-mediated NF-kappa B activation by inhibiting TRAF6 polyubiquitination, Cell Research 23(3): 366-377.
- Zhang, X.F.; Zhang, J.; Zhang, L.; Dam, H. van & Dijke, P. ten (2013), UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination., Cell Research.
- Zhang, L.; Zhou, F.F.; Li, Y.H.; Drabsch, Y.; Zhang, J.; Dam, H. van & Dijke, P. ten (2012), Fas-associated Factor 1 Is a Scaffold Protein That Promotes beta-Transducin Repeat-containing Protein (beta-TrCP)-mediated beta-Catenin Ubiquitination and Degradation, Journal of Biological Chemistry 287(36): 30701-30710.
- Sundqvist, A.; Zieba, A.; Vasilaki, E.; Hidalgo, C.H.; Soderberg, O.; Koinuma, D.; Miyazono, K.; Heldin, C.H.; Landegren, U.; Dijke, P. ten & Dam, H. van (2012), Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion., Oncogene.
- Zhang, L.; Huang, H.Z.; Zhou, F.F.; Schimmel, J.; Pardo, C.G.; Zhang, T.T.; Barakat, T.S.; Sheppard, K.A.; Mickanin, C.; Porter, J.A.; Vertegaal, A.C.O.; Dam, H. van; Gribnau, J.; Lu, C.X. & Dijke, P. ten (2012), RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation, Molecular Cell 46(5): 650-661.
- Zhou, F.F.; Zhang, X.F.; Dam, H. van; Dijke, P. ten; Huang, H.Z. & Zhang, L. (2012), Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation, Journal of Biological Chemistry 287(14): 11002-11010.
- Naber, H.P.H.; Wiercinska, E.; Pardali, E.; Laar, T. van; Nirmala, E.; Sundqvist, A.; Dam, H. van; Horst, G. van der; Pluijm, G. van der; Heckmann, B.; Danen, E.H.J. & Dijke, P. ten (2012), BMP-7 inhibits TGF-beta-induced invasion of breast cancer cells through inhibition of integrin beta(3) expression, Cellular Oncology 35(1): 19-28.
- Sundqvist, A.; Dijke, P. ten & Dam, H. van (2012), Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity., Breast Cancer Research 14(1): 204.
- Zhou, F.F.; Zhang, L.; Laar, T. van; Dam, H. van & Dijke, P. ten (2011), GSK3 beta inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb, Molecular Biology of the Cell 22(18): 3533-3540.
- Wiercinska, E.; Naber, H.P.H.; Pardali, E.; Pluijm, G. van der; Dam, H. van & Dijke, P. ten (2011), The TGF-beta/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system, Breast Cancer Research and Treatment 128(3): 657-666.
- Zhang, L.; Zhou, F.F.; Laar, T. van; Zhang, J.; Dam, H. van & Dijke, P. ten (2011), Fas-associated factor 1 antagonizes Wnt signaling by promoting beta-catenin degradation, Molecular Biology of the Cell 22(9): 1617-1624.
- Roukens, M.G.; Alloul-Ramdhani, M.; Baan, B.; Kobayashi, K.; Peterson-Maduro, J.; Dam, H. van; Schulte-Merker, S. & Baker, D.A. (2010), Control of endothelial sprouting by a Tel-CtBP complex, Nature Cell Biology 12(10): 933-942.
- Ramos, Y.F.M.; Hestand, M.S.; Verlaan, M.; Krabbendam, E.; Ariyurek, Y.; Galen, M. van; Dam, H. van; Ommen, G.J.B. van; Dunnen, J.T. den; Zantema, A. & Hoen, P.A.C. 't (2010), Genome-wide assessment of differential roles for p300 and CBP in transcription regulation, Nucleic Acids Research 38(16): 5396-5408.
- Baan, B.; Pardali, E.; Dijke, P. ten & Dam, H. van (2010), In Situ Proximity Ligation Detection of c-Jun/AP-1 Dimers Reveals Increased Levels of c-Jun/Fra1 Complexes in Aggressive Breast Cancer Cell Lines in Vitro and in Vivo, Molecular and Cellular Proteomics 9(9): 1982-1990.
- Matic, I.; Schimmel, J.; Hendriks, I.A.; Santen, M.A. van; Rijke, F. van de; Dam, H. van; Gnad, F.; Mann, M. & Vertegaal, A.C.O. (2010), Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif, Molecular Cell 39(4): 641-652.
- Diefenbacher M, Sekula S, Heilbock C, Maier JV, Litfin M, van Dam H, Castellazzi M, Herrlich P & Kassel O (2008), Restriction to fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1, Molecular Endocrinology -Baltimore- 22(8).
- Hamdi M, Popeijus HE, Carlotti F, Janssen JM, van der Burgt C, Cornelissen-Steijger P, van de Water BV, Hoeben RC, Matsuo K & van Dam H (2008), ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses, DNA Repair 7(3).
- Eichhorn PJA, Creyghton MP, Wilhelmsen K, van Dam H & Bernards R (2007), A RNA interference screen identifies the protein phosphatase 2A subunit PR55 gamma as a stress-sensitive inhibitor of c-SRC, PLoS Genetics 3(12).
- Baan B, van Dam H, van der Zon GCM, Maassen JA & Ouwens DM (2006), The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2, Molecular Endocrinology -Baltimore- 20(8).
- Hamdi M, Kool J, Cornelissen-Steijger P, Carlotti F, Popeijus HE, van der Burgt C, Janssen JM, Yasui A, Hoeben RC, Terleth C, Mullenders LH & van Dam H (2005), DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1, Oncogene 24(48).
- Le NH, van der Wal A, van der Bent P, Lantinga-van Leeuwen IS, Breuning MH, van Dam H, de Heer E & Peters DJM (2005), Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease, Journal of the American Society of Nephrology 16(9).
- Papassava P, Gorgoulis VG, Papaevangeliou D, Vlahopoulos S, van Dam H & Zoumpourlis V (2004), Overexpression of activating transcription factor-2 is required for tumor growth and progression in mouse skin tumors, Cancer Research 64(23).
- Le NH, van der Bent P, Huls G, van de Wetering M, Loghman-Adham M, Ong ACM, Calvet JP, Clevers H, Breuning MH, van Dam H & Peters DJM (2004), Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected, Journal of Biological Chemistry 279(26).
- Kool J, Hamdi M, Cornelissen-Steijger P, van der Eb AJ, Terleth C & van Dam H (2003), Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2, Oncogene 22(27).
- Ouwens DM, de Ruiter ND, van der Zon GCM, Carter AP, Schouten J, van der Burgt C, Kooistra K, Bos JL, Maassen JA & van Dam H (2002), Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38, EMBO Journal 21(14).
- van Dam H & Castellazzi M (2001), Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis, Oncogene 20(19).
- Perez S, Vial E, van Dam H & Castellazzi M (2001), Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation, Oncogene 20(9).
- De Ruiter ND, Wolthuis RMF, van Dam H, Burgering BMT & Bos JL (2000), Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ra1 guanine nucleotide exchange factor-Ra1 pathway, Molecular and Cellular Biology 20(22): 8480-8488.
- Huguier S, Baguet J, Perez S, van Dam H & Castellazzi M (1998), Transcription factor ATF2 cooperates with v-Jun to promote growth factor-independent proliferation in vitro and tumor formation in vivo, Molecular and Cellular Biology 18(12): 7020-7029.
- van Dam H, Huguier S, Kooistra K, Baguet J, Vial E, van der Eb AJ, Herrlich P, Angel P & Castellazzi M (1998), Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation, Genes and Development 12(8): 1227-1239.