I am interested in how secondary metabolite diversity comes about and why it is maintained in nature. More specifically, I would like to understand the evolution of pyrrolizidine alkaloid diversity among and within Jacobaea species.
2014-present: PhD project on the evolution of pyrrolizidine alkaloid diversity among and within Jacobaea species. Promotors: Prof.dr. Peter Klinkhamer & Prof.dr. Johan Memelink. Co-promotor: Dr. Klaas Vrieling
2013-2014: Research Assistant at Beijing University of Chinese Medicine
2010-2013: MSc Chinese Medicine at University of Macau
2006-2010: BSc Pharmacy at Wuhan University
Plants produce a huge variety of secondary metabolites which are thought to be involved in the protection of plants against herbivores. The most characteristic features of SMs are their striking chemical diversity and inter- or intraspecific variation. As yet, it is poorly understood from an evolutionary point of view how secondary metabolite diversity comes about and why it is maintained in nature.
My research concerns the evolution of pyrrolizidine alkaloid, a typical class with a high diversity, among and within Jacobaea species which all produce alkaloids but the concentration and composition are highly species-specific. I have investigated in de novo and comparative transcriptome study of Jacobaea vulgaris and Jacobaea aquatica. Furthermore, I compare metabolic and transcriptomic profiles of Jacobaea vulgaris induced by methyl jasmonate to its control to investigate catalytic genes involved in alkaloid biosynthesis, especially cytochrome P450s. I have tried to reconstruct the evolutionary history of PA variation using different Jacobaea species based on LC-MS/MS data and molecular characters. I hope to gain a better insight into the mechanism of alkaloid diversity.
- Wiskunde en Natuurwetenschappen
- Instituut Biologie Leiden
- IBL Plant Sciences & Natural Products
No relevant ancillary activities