Universiteit Leiden

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Xiansha Xiao

X. Xiao MSc

I was graduated from Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, as a master student. My research was focused on the structural and functional analysis of some potential drug-target proteins in Mycobacterium tuberculosis and some industrial potential catalytic enzymes. Now my PhD projects are mainly focused on the cell division regulation and the gene cluster and enzymes involved in new antibiotic discovery in Streptomyces.

More information about Xiansha Xiao

Streptomyces are multicellular bacteria whose cell division process is quite different from unicellular bacteria. To have a better understanding of how cell division process is controlled, we used molecular biology, microscopy and crystallography to analyze the temporal and spatial regulation of this process. In addition, Streptomyces are the producers of 60% antibiotics all over the world. Some of the potential antibiotics were identified in our group. But the synthetic pathways of those compounds are not clear yet. To elucidate how they are produced, we aim at finding the key enzyme. Further, we’re going to use this enzyme to modify more known antibiotics to produce more potential new antibiotics. To achieve this goal, I used crystallography and in vitro activity assay to analyze the drug-target interactions.

PhD candidate

  • Wiskunde en Natuurwetenschappen
  • Instituut Biologie Leiden
  • IBL Microbial Sciences

Work address

Sylviusweg 72
2333 BE Leiden
Room number 4.5.13


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