In 2008 I started my studies in bio-pharmaceutical sciences at the Leiden University. Over the course of my bachelor’s degree I gained interest in the fields of drug discovery and medicinal chemistry, and had led me to perform my BSc research project at the department of Medicinal Chemistry, under the tutelage of Prof. Ad IJzerman.
Following my BSc degree I decided to continue my training in biopharmaceutical sciences and performed both research projects in the field of medicinal chemistry. During a 9-month internship which I again performed in Prof. IJzerman’s group, I worked on the synthesis of a novel class of CCR2 antagonists. For my final research project I moved abroad, and joined the group of Prof. Barrie Kellam at the University of Nottingham. Here, I worked on developing small molecule-based fluorescent probes for the adenosine receptor A3R.
After completing my Msc degree in biopharmaceutical sciences I was offered the opportunity to return to the University of Nottingham as a Marie Curie PhD fellow. Part of the ONCORNET consortium, I closely worked together with some 14 other PhD fellows spread across some of the top GPCR labs in Europe. During my 3-year fellowship I used structure-based approaches for the design and synthesis of fluorescent ligands for the chemokine receptors CXCR4 and CXCR7. Additionally, I gained experience in using these ligands in NanoBRET-based assays and confocal microscopy.
Since November 2018 I have been doing a postdoc in the group of Dr. Laura Heitman, where I am working on developing affinity-based probes for the chemokine receptor CCR2 and implementing chemical biology-methodologies for the study of GPCRs.
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal Chemistry
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