Universiteit Leiden

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Navraj Pannu

Assistant professor

Dr. N.S. Pannu
+31 71 527 4414

Navraj Pannu's research focuses on developing computational methods to determine the three dimensional structures of macromolecules and to apply these methods to solve medically and technologically relevant structures.

More information about Navraj Pannu

Curriculum Vitae

Personal information

Nationality:   Canadian (Permanent Dutch resident)
Date of birth:   18 January 1974


2002   Trinity College, University of Cambridge, United Kingdom, 20 July 2002
Thesis title: ‘Development of methods in macromolecular crystallography with applications to the study of diseases’
1991     MSc in Applied Mathematics, Faculty of Science, University of Alberta, Canada.

Current and previous research positions

2001 – now     Assistant Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands.
2000 – 2006   Title A Research Fellow, Trinity College, University of Cambridge, United Kingdom.

Grants, awards, recognitions since 2010

2016   NWO Building Blocks of Life grant (co-applicant)
2016   ZonMw Middelgroot grant (main applicant)
2013   STW High Tech Systems and Materials (HTSM) grant
2010   Cyttron II/CCP4 grant

Contribution to teaching and supervision

  • Undergraduate course ‘Analytical Chemistry’ for BSc Molecular Science and Technology (with Fillipov)
  • Course ‘Biomolecular Structures’ for MSc Chemistry at Leiden University (with Ubbink and Abrahams).
  • Supervision of 7 PhD students and 2 postdoctoral fellows since 2010. Current employment of recent PhD students and postdocs: M. van Roon MRC-LMB, Cambridge; P. Skubak, Leiden University; W-J. Waterreus, ZoBio BV; E. Meulenbroek, Sanquin; I. Sikharulidze, Diamond Synchrotron, Oxford (UK); S. Ness, University of Victoria; D. Georgieva, Roche.

Other responsibilities since 2010

  • ŸScientific Advisory Board member of the Lorentz Center Life and Medical Sciences (since 2014)
  • ŸChair of the “Computational methods in macromolecular crystallography” session at the European Crystallographic Association meeting, 21-26 August 2015, Rovinj, Croatia
  • ŸNWO ECHO Chemistry of Life Assessment Committee, 2012, 2014
  • ŸMember of review panel for beam line 14, European Synchrotron Radiation Facility (ESRF) beam time
  • ŸReviewer for Nature Methods, Nature Protocols, Acta Crystallographica, Structure

Publication record including five recent representative publications

Ca. 50 papers with >28 000 citations, H-index 21 (Google scholar)

Full publication record: Google Scholar

  • ŸDijk M., Holkers J., Voskamp P., Giannetti B.M., Waterreus W.-J., Veen H.A. van, Pannu N.S., How dextran sulfate affects C1-inhibitor activity: a model for polysaccharide potentiation. Structure. 2016 (in press).
  • ŸKuzmanic A., Pannu N.S., Zagrovic B., X-ray refinement significantly underestimates the level of microscopic heterogeneity in biomolecular crystals. Nature Communications. 2014, 5, 3220.
  • ŸSkubak P., Pannu N.S., Automatic protein structure solution from weak X-ray data. Nature Communications. 2014, 4, 2777.
  • ŸMeulenbroek E.M., Cane C.P., Jala I., Iwai S., Moolenaar G.F., Goosen N., Pannu N.S., UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions. Nucleic Acids Research. 2013, 41(2), 1363-1371.
  • ŸWinn M.D., Ballard C.C., Cowtan K.D., Dodson E.J., Emsley P., Evans P.R., Keegan R.M., Krissinel E.B., Leslie A.G.W., McCoy A., McNicholas S.J., Murshudov G.N., Pannu N.S., Potterton E.A., Powell H.R., Read R.J., Vagin A., Wilson K.S., Overview of the CCP4 suite and current developments. Acta Crystallographica. 2011, D67, 235-242.

Presentations including five presentations at international conferences since 2010

>50 invited presentations at universities, companies and invited and plenary lectures at international conferences since 2010

  • Ÿ‘Interatomic distances and heterogeneity in crystals’, ESRF Users meeting, 8-10 February 2016, ESRF Synchrotron, Grenoble (France), keynote lecture
  • Ÿ‘CRANK2 – a pipeline for SAD and MR-SAD data’, Structural Biology Grid, Harvard Medical School, 15 March 2016, Cambridge (USA), invited lecture.
  • Ÿ‘Automated protein structure solution for weak SAD data’, Japanese Crystallographic Association Annual Meeting, 1-3 November 2014, Tokyo (Japan), invited lecture
  • Ÿ‘Automated protein structure solution’, Advanced Methods of Crystallography, 22-25 June 2014, Australian Synchrotron, Melbourne (Australia), invited lecture
  • Ÿ‘Advances in experimental phasing’, From data processing to structure refinement and beyond workshop, 9-17 April 2013, Institute Pasteur, Montevideo (Uruguay), invited lecture

Assistant professor

  • Wiskunde en Natuurwetenschappen
  • Leiden Institute of Chemistry
  • LIC/Biophysical Structural Chemistry

Work address

Science Campus
Einsteinweg 55
2333 CC Leiden
Room number DM224


Assistant professor / guest

  • Wiskunde en Natuurwetenschappen
  • Leiden Institute of Chemistry
  • LIC/Biophysical Structural Chemistry

Work address

Science Campus
Einsteinweg 55
2333 CC Leiden
Room number DM2.24



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