Postdoc / guest
Miriam Peeters is a senior scientist at the Division of Medicinal Chemistry. Her current research is focussed on Adhesion GPCRs.
In 2006, I received my Master of Science degree in Molecular Life Sciences at the Radboud University in Nijmegen. In January 2007, I came to Leiden to start my PhD at the department of Medicinal Chemistry on a project that was part of a TI Pharma initiative. Here, I focused on the activation mechanism of GPCRs and more specifically on the extracellular loops of class A GPCRs, the most non-conserved regions of these receptors that were thought to be unimportant in the activation mechanism. For this purpose, I developed new screening methods to identify mutations that influence receptor activation.
My research provided profound evidence that the extracellular loops are in fact main determinants in the activation mechanism, providing the unique character of each individual receptor. The relevance of my research was awarded by a number of (inter)national prizes and publications, and in November 2011, I received my doctorate.
In September 2011, I moved to the University of Copenhagen at the Novo Nordisk Foundation Center for Basic Metabolic Research in the lab of Prof. Schwartz for a post-doc position. After working in Copenhagen for one year, I got the opportunity to continue the project at the department of Medicinal Chemistry in Leiden as part of a newly established, international Danish-Dutch alliance. In this collaboration, I move my focus towards a new class of GPCRs: the Class B, and more specifically, the Adhesion GPCRs.