Michiel van Esdonk
Michiel van Esdonk (M.Sc.) is a PhD student at the Division of Pharmacology.
Michiel van Esdonk started his PhD at the Division of Pharmacology in 2015 after the completion of his MSc studies in Bio-pharmaceutical Sciences at Leiden University. During his MSc studies, he did his internships at the Division of Pharmacology of Leiden University and at the pharmacometrics group of the University of Queensland, Brisbane. During these internships, he gained knowledge in the use of non-linear mixed effects modeling in different research areas, such as brain distribution modeling and type 1 diabetes.
His PhD research is focused on the development of pharmacokinetic and pharmacodynamic (PKPD) models to better understand and quantify changes in the neuroendocrine system. These changes may be the result from diseases that influence the functioning of the pituitary, an important hormone gland in the human body, or an effect that is driven by an individual’s drug treatment. Also, the quantification of drug effects using PKPD models in early stage clinical trials (phase I studies) that target the pituitary will be investigated.
The work of Michiel is in close collaboration with the Centre for Human Drug Research, located in the Bio Science Park of Leiden.