Manuel Gonzalez Hernandez
I am a postdoc at the Leiden Academic Centre for Drug Research (LACDR) with professor Gerard van Westen at the Computational Drug Discovery group. I came from Mexico in 2014 to the amazing city of Maastricht, where I pursued my MSc and PhD in biomedical sciences at Maastricht University with professor Ellen Blaak. My main project I am working on is MechPath (Mechanistic Pathology understanding), which aims to get insight into the variability on fibrosis gene expression profiles and relate to disease pathology and identify patient specific pathway patterns to stratify into groups and subgroups of patients. Moreover, identify how patient variety can be represented in preclinical in vitro models. This project has the collaboration of various parties, including LACDR, TNO, Galapagos and Proefdirvrij. A strong point about the MechPath project is the combination of various disciplines including the bioinformatics, biological in vitro insight together with the experience from AI Computational methods including Machine Learning models and Cheminformatics modeling. My PhD focused on metabolism from a Biological perspective, including physiology, lipid metabolism and insulin sensitivity at the tissue and systemic levels. During this time, I investigated the effect of gut derived metabolites (acetate, propionate and butyrate) on lipid metabolism (fat oxidation and lipolysis) in human primary adipocytes and muscle cells. Additionally, I investigated the relationship of these metabolites and proteolytic fermentation byproducts with metabolic health and insulin sensitivity from large cohort studies, performing biological data analysis. I recently joined the computational group at LACDR, which has a great atmosphere with colleagues from a diverse background including the chemistry and biology groups. See my linkedin website for more information (mgonzalezh12).
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