Universiteit Leiden

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Lindsey Burggraaff

PhD candidate

L. Burggraaff MSc
+31 71 527 4319

Lindsey Burggraaff is a Ph.D. student at the Division of Medicinal Chemistry and works on a computational approach to predict target selectivity of ligands.

More information about Lindsey Burggraaff

Before I started as a PhD student at Leiden University I studied Pharmaceutical Sciences at VU Amsterdam. In 2013 I obtained my Bachelor’s degree and decided to do the follow-up research master “Drug Discovery & Safety”. During this master I completed the specialization courses of both “Drug Discovery & Target Finding” and “Computational Medicinal Chemistry & Toxicology”. Although I always had a certain interest in computational chemistry, my interest in computational medicinal chemistry was strengthened by my challenging major internship in the medicinal chemistry group at the VU where I focused on obtaining selectivity in phosphodiesterases. I graduated and received my Master’s degree in “Drug Discovery & Safety” with a specialization in “Computational Medicinal Chemistry & Toxicology” in 2015.

Currently I am doing my PhD research in the medicinal chemistry group of Prof. IJzerman. Under the lead of Dr. van Westen I will work on a computational approach to predict target selectivity of ligands. The main focus will be on proteochemometric (PCM) modeling of G protein-coupled receptors (GPCRs). With this technique protein information and ligand data are combined and cross-linked, resulting in predictive models. Subsequently, these models can be applied to predict selectivity of ligands in mutated carcinogenic receptors. Ultimately, these models may guide personalized medicine based on genotypic information.

PhD candidate

  • Wiskunde en Natuurwetenschappen
  • Leiden Academic Centre for Drug Research
  • LACDR/Medicinal Chemistry

Work address

Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
Room number EM4.18


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