PhD candidate / guest
Indira Nederpelt is a Ph.D. student at the Division of Medicinal Chemistry. She designs and uses radioligand binding studies and cell based assays to characterize in vitro residence time properties of agonists/antagonists for several GPCRs.
I was first introduced to the department of Medicinal Chemistry during my Bachelor Bio-Pharmaceutical Sciences, while I was taking a 3-week practical course within the department. Quickly I became very enthusiastic about the research that was conducted in this lab and therefore I chose to do my 10-week bachelor internship at Medicinal Chemistry working on the in vitro characterization of the GnRH receptor.
I continued to work on this project during the first internship of my Master Bio-Pharmaceutical Sciences. Within this 9-month master internship I also had the chance to work on a second project concerning another GPCR; the CCR2 Chemokine Receptor. This CCR2 project was in collaboration with Vertex Pharmaceuticals Inc. located in San Diego, California and ultimately resulted in an opportunity for my second master internship.
For 6 months I worked at the biology department of Vertex Pharmaceuticals contributing to an ongoing pain project working with a specific receptor tyrosine kinase. I performed multiple biological assays researching the extracellular binding site and the intracellular kinase domain of the receptor.
After finishing my Masters degree I returned to the division of Medicinal Chemistry to work as a PhD student, starting in January 2013. A common thread in my internships at Medicinal Chemistry was the search for long acting agonists/antagonists for their respective receptor. For decades drug-target affinity was the most conventional measure in finding new drugs, but recently the total duration of a drug-receptor interaction, so called ‘residence time’, has emerged to have an essential role in the selectivity and efficacy of the drug. During my four years as a PhD student I will design and use radioligand binding studies and cell based assays to characterize in vitro residence time properties of agonists/antagonists for several GPCRs.
No relevant ancillary activities