Postdoc / guest
Dong Guo is a postdoc researcher at the Division of Medicinal Chemistry. His current research area involves the application of mathematical modeling for molecular understanding of ligand-receptor binding kinetics.
I studied biopharmaceutical science at the Western China School of Pharmacy, Sichuan University. After obtaining my Bachelor degree in 2007, I joined a cooperation project between Sichuan University and Leiden University (Netherlands), which allowed me to study Biopharmaceutical Sciences at the then Leiden/Amsterdam Center for Drug Research (Now Leiden Academic Centre for Drug Research, LACDR).
During this stage I performed two master projects in Prof. Ad IJzerman’s group at the Division of Medicinal Chemistry. The first one was organic chemistry based and the second had a molecular biology / pharmacology flavor. Later in my master study (2008), I did a third internship at the University of Copenhagen (Denmark) under the guidance of Prof. Mette Rosenkilde and Prof. Thue Schwartz.
After obtaining my master in Biopharmaceutical Sciences in 2009, I started my doctorate project on “Drug-target residence time—a case for the adenosine A1 and A2A receptors” under the supervision of Prof. Ad IJzerman and Dr. Laura Heitman at the Division of Medicinal Chemistry (Jan, 2010 – Jan, 2014). During this stage, I developed and optimized several kinetics assays and gained knowledge of ligand-receptor residence time at the adenosine A1 and A2A receptors. This has led to a scientific ‘output’ of six articles and one book chapter. Moreover, I have presented my research at several (inter)national congresses and received five prizes.
Following this doctorate study, I joined the K4DD consortium, which is financially supported by Europe’s Innovative Medicines Initiative (IMI) program and major Pharma companies, as a postdoctoral scientist at the same division (Jan, 2014). This opportunity definitely allows me to continue my interest in understanding ligand-receptor binding kinetics, especially in the field of GPCRs.
My current research area involves the application of mathematical modeling for molecular understanding of ligand-receptor binding kinetics.
No relevant ancillary activities